Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth

Cancer Letters
Susan BardoczIan F Pryme

Abstract

The number of Krebs II tumour cells recovered from the ascitic fluid of mice fed for 8 days on a lactalbumin (La) control diet was about three times higher than that in animals fed a phytohaemagglutinin-containing (PHA) diet. Feeding a PHA diet for less than 8 days after tumour cell injection also led to a reduction in tumour cell growth. There was an apparent inverse relationship between the total tumour cell count and the intracellular content of putrescine, spermidine and spermine. Hyperplasia of the small intestine occurred in the mice during the development of the ascites. A series of other organs were not affected in the same manner. The results indicate that the polyamine content of Krebs II ascites cells must increase by more than three-fold in order to achieve the intracellular concentration necessary to be able to enter the S-phase. A partial synchronization of the tumour cell population is suggested. Hyperplastic growth of the small intestine would appear to compete with tumour cells for polyamines from a common body pool.

References

Nov 1, 1991·The British Journal of Nutrition·L A RubioArpad Pusztai
Apr 1, 1990·Trends in Biochemical Sciences·O Heby, L Persson
Oct 1, 1993·Journal of Clinical Periodontology·U van der VeldenE G Winkel
Aug 1, 1996·The International Journal of Biochemistry & Cell Biology·N SeilerJ P Moulinoux

Citations

Mar 26, 2004·Cancer Detection and Prevention·Ian F PrymeUwe Pfüller
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Elvira González De Mejía, Valentin I Prisecaru
Sep 21, 2001·European Journal of Gastroenterology & Hepatology·Ian F Pryme, Susan Bardocz
Mar 21, 2007·Biochemical Society Transactions·Ian F Pryme
Oct 9, 2019·International Journal of Biological Macromolecules·Ajay Kumar GautamKhem Chand Saini

Related Concepts

Metazoa
Cell Division Phases
Heart
Hyperplasia
Intestines, Small
Kidney
Reticulosarcoma
Mice, Inbred Strains
Neoplasm Transplantation
Phytohemagglutinins

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