PMID: 6468727Jan 1, 1984

Intracellular localization and characterization of 3-hydroxykynureninase in human liver

The International Journal of Biochemistry
J InadaR Kido


3-hydroxykynureninase in human liver was present in cytosol and mitochondria. The cytosolic enzyme and mitochondrial enzyme had the same physiological and enzymic properties. The enzyme had a mol. wt of 130,000 by gel filtration and isoelectric point of pH 5.9. The enzyme was active for 3-hydroxykynurenine and kynurenine, and its activity ratio was 15:1. The apparent Km values of the enzyme were 7.7 X 10(-5) M for 3-hydroxykynurenine, 1.0 X 10(-3) M for kynurenine and 2.5 X 10(-6) M for pyridoxal 5'-phosphate with 3-hydroxykynurenine. Some other properties of purified enzymes are described.


Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·T IshikawaR Kido
May 5, 2017·International Journal of Tryptophan Research : IJTR·Abdulla A-B Badawy
May 27, 2016·International Journal of Tryptophan Research : IJTR·H BaranB Kepplinger
May 20, 2015·International Journal of Tryptophan Research : IJTR·Katsumi ShibataTsutomu Fukuwatari
Apr 26, 2013·The Journal of Nutrition·Chiaki HiratsukaKatsumi Shibata


Jul 31, 1973·Biochemistry·M MoriguchiK Soda
Aug 6, 1971·Biochemical and Biophysical Research Communications·M MoriguchiK Soda

Related Concepts

Enzymes, antithrombotic
Pyridoxal Phosphate
Mitochondria, Liver
Gel Chromatography
Enzymes for Treatment of Wounds and Ulcers
Enzymes, hematological

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