Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

Biochimica Et Biophysica Acta
Yusuke OhnoYasuyuki Igarashi

Abstract

Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein.

References

Jan 2, 1992·Gene·T W ChristiansonP Hieter
Jan 20, 1995·The Journal of Biological Chemistry·L J RobinsonT Michel
Dec 1, 1994·Computer Applications in the Biosciences : CABIOS·M G Claros, G von Heijne
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyA G Gilman
Dec 5, 1998·Biochimica Et Biophysica Acta·J T Dunphy, M E Linder
May 22, 2002·The Journal of Biological Chemistry·Baojie LiStephen P Goff
Aug 24, 2002·The Journal of Biological Chemistry·Sandra LoboRobert J Deschenes
Oct 9, 2002·The Journal of Cell Biology·Amy F RothNicholas G Davis
Oct 24, 2002·Human Molecular Genetics·Roshni R SingarajaMichael R Hayden
Nov 2, 2002·The Journal of Biological Chemistry·Chie OgawaYasuyuki Igarashi
Apr 16, 2003·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takeshi HaradaEisuke Nishida
Jun 9, 2004·Nature Genetics·Jun MukaiJoseph A Gogos
Jul 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cheryl A KellerBernhard Lüscher
Dec 18, 2004·Neuron·Masaki FukataDavid S Bredt
May 26, 2005·European Journal of Human Genetics : EJHG·Mahmoud Reza MansouriNiklas Dahl
Jun 24, 2005·The EMBO Journal·Javier Valdez-Taubas, Hugh Pelham
Jul 8, 2005·The Journal of Biological Chemistry·John T SwarthoutMaurine E Linder
Sep 28, 2005·The Journal of Cell Biology·Jessica E SmotrysMaurine E Linder
Oct 18, 2005·Molecular and Cellular Biology·Akio KiharaYasuyuki Igarashi

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Citations

Feb 9, 2012·Cellular and Molecular Life Sciences : CMLS·Chandan SharmaMartin E Hemler
Jul 20, 2011·Cell Host & Microbe·Stuart W HicksJorge E Galán
Jun 15, 2007·Biochemistry·Yannick MarrariPhilip B Wedegaertner
Dec 12, 2012·ACS Chemical Biology·Christopher T M B Tom, Brent R Martin
Sep 17, 2011·Chemical Reviews·Howard C Hang, Maurine E Linder
May 21, 2010·Nature Reviews. Neuroscience·Maria KarayiorgouJoseph A Gogos
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sookhee ParkCatherine A Fox
Sep 20, 2011·The Journal of Biological Chemistry·Oforiwa A GorlekuLuke H Chamberlain
Jul 4, 2008·The Journal of Biological Chemistry·Jennifer GreavesLuke H Chamberlain
Oct 6, 2009·Molecular & Cellular Proteomics : MCP·Wei YangMichael R Freeman
May 30, 2008·Molecular Biology of the Cell·Chandan SharmaMartin E Hemler
Apr 8, 2011·Molecular Biology of the Cell·Jennifer GreavesLuke H Chamberlain
Jun 4, 2011·Human Molecular Genetics·Kun HuangMichael R Hayden
Mar 21, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kun HuangAlaa El-Husseini
Jan 5, 2011·Eukaryotic Cell·Brian T EmmerDavid M Engman
Jan 30, 2013·Molecular and Cellular Biology·Akiyuki Nishimura, Maurine E Linder
Aug 3, 2011·Molecular and Cellular Biology·Sharon EisenbergYoav I Henis
Mar 25, 2011·Journal of Cell Science·Jennifer Greaves, Luke H Chamberlain
Jul 25, 2014·PLoS Neglected Tropical Diseases·María C MerinoAndrea S Rópolo
Jul 5, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Raja BhattacharyyaDora M Kovacs
Nov 5, 2013·International Journal for Parasitology·Karine FrénalDominique Soldati-Favre
May 14, 2014·The Journal of General Physiology·Michael J Shipston
Jun 24, 2014·Trends in Parasitology·Amanda M GoldstonDavid M Engman
Oct 25, 2012·Journal of Biomedicine & Biotechnology·Maria Martha CorviMarina Cecilia Caballero
Sep 5, 2013·Molecular and Cellular Biology·Wenying RenKeyong Du

❮ Previous
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