Intracellular localization of palmitoyl-CoA hydrolase and palmitoyl-CoA synthetase in human blood platelets and liver

Scandinavian Journal of Clinical and Laboratory Investigation
R K BergeM Farstad

Abstract

The intracellular localization studies of human blood platelets by sucrose gradient and differential centrifugation, showed that palmitoyl-CoA hydrolase was mainly localized in the cytosol fraction. However, a localization also in the mitochondrial fraction seems possible as disruption of platelets by the French press and nitrogen decompression techniques resulted in mitochondrial damage. In human liver the palmitoyl-CoA hydrolase was localized in the mitochondrial and microsomal fractions. Palmitoyl-CoA synthetase was localized in the mitochondrial and microsomal fractions in both platelets and liver. The possible physiological implications of these differences, and the finding of a very high ratio of palmitoyl-CoA hydrolase/palmitoyl-CoA synthetase in platelets compared with liver, are discussed.

References

Dec 1, 1978·Scandinavian Journal of Clinical and Laboratory Investigation·R K Berge, M Farstad
Jul 22, 1975·Biochimica Et Biophysica Acta·J I PedersenM Aas
Feb 1, 1979·Scandinavian Journal of Clinical and Laboratory Investigation·S E Vollset, M Farstad
Jan 1, 1966·The Journal of Clinical Investigation·A J MarcusH L Ullman
Mar 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·M FarstadJ Sander
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Nov 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·M Farstad, J Sander
Jul 1, 1968·The Journal of Cell Biology·C Schnaitman, J W Greenawalt

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Citations

Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·K J Andersen, R K Berge
Oct 24, 1998·Clinical and Experimental Pharmacology & Physiology·K M Knights
May 1, 1983·Neurochemical Research·C Trevisan, S DiMauro
Jul 13, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S YamaoriK Watanabe
Nov 3, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Shengjun Qiao, Pentti Tuohimaa
Jan 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·M Farstad

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