Intracellular localization of rotaviral proteins.

Archives of Virology
S C RichardsonI H Holmes


The differential distribution of two SA 11 rotaviral capsid antigens in thin sections of infected cells was examined using antibody-coated colloidal gold electron-dense particles as specific post-embedding immunocyto-chemical labels. The treatment of thin sections of conventionally fixed and embedded tissue specimens with sodium metaperiodate allowed specific localization of the antigens in tunicamycin-treated, infected CV-1 cells. Both protein antigens were investigated with specific anti-rotavirus hyper-immune sera and with specific monoclonal antibodies. These studies showed that the major outer capsid glycoprotein, gp34, of SA11 rotavirus particles was mainly located within the cisternae and along the membranes of the rough endoplasmic reticulum. The antigen of the major inner capsid protein, p42, was identified attached to enveloped virus particles, and even more obviously, on laminar crystalline structures in the nucleus and cytoplasm of the infected cells.


Jan 1, 1979·Archives of Virology·J CohenR Scherrer
Jul 1, 1978·The Journal of General Virology·M S McNulty
Apr 1, 1977·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Horisberger, J Rosset
Jan 1, 1967·Archiv für die gesamte Virusforschung·H H Malherbe, M Strickland-Cholmley
Jan 1, 1984·Virus Research·B L PetrieM K Estes
May 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J RothM Garavito
Jan 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Bendayan, M Zollinger
Jan 1, 1980·The Journal of General Virology·B C AltenburgM K Estes
Oct 1, 1981·The Journal of General Virology·E Novo, J Esparza
Jan 1, 1981·Intervirology·B L PetrieM K Estes
Sep 1, 1982·Journal of Virology·M SabaraV Misra
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Apr 1, 1983·Journal of Virology·B L PetrieD Y Graham
Mar 1, 1983·Journal of Virology·S SonzaI H Holmes
Jan 1, 1980·Journal of Immunological Methods·G Müller, C L Baigent

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Jul 26, 2019·ELife·Yasel Garcés SuárezCarlos F Arias
Dec 1, 1989·Microbiological Reviews·M K Estes, J Cohen
Jun 1, 1990·Journal of Virology·D R Maass, P H Atkinson
Aug 1, 1988·Journal of Virology·A K KabcenellP H Atkinson

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