Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(ii) superoxide dismutase mimic complex.

Chemical Communications : Chem Comm
Emilie MathieuClotilde Policar

Abstract

A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.

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Methods Mentioned

BETA
X-ray
electron paramagnetic resonance
chemical fixation
infrared spectromicroscopy

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