Intracellular location of BRCA2 protein expression and prostate cancer progression in the Swedish Watchful Waiting Cohort

Carcinogenesis
Tryggvi ThorgeirssonTransdisciplinary Prostate Cancer Partnership (ToPCaP)

Abstract

Prostate cancer patients with inherited BRCA2 mutations have a survival disadvantage. However, it is unknown whether progression is associated with BRCA2 protein expression in diagnostic prostate cancer tissue, among men without inherited mutations. We conducted a nested case-control study within the Swedish Watchful Waiting cohort. The case group included all 71 patients who died from prostate cancer within 5 years from diagnosis and controls were all patients (n = 165) who lived at least 7 years after diagnosis. Tissue microarrays were stained using antibodies for C- and N-terminal domains of the BRCA2 protein. Location (nuclear, cytoplasmic and membranous) and magnitude (intensity and percentage) of expression were assessed. Logistic regression models produced odds ratios (OR) and 95% confidence intervals (CI) adjusted for age, year of diagnosis and Gleason score. Positive BRCA2 staining at the cell membrane was associated with reduced risk of death within 5 years (N-terminal: OR = 0.47, 95% CI = 0.21-1.04, P = 0.06; C-terminal: OR = 0.41, 95% CI = 0.18-0.91, P = 0.03) and low Gleason scores (P = 0.006). Positive cytoplasmic C-terminal staining was associated with higher Gleason scores and increased lethality (OR = 3.61, 95%...Continue Reading

References

Jan 1, 1985·Statistics in Medicine·J Cuzick
Oct 1, 1985·Statistics in Medicine
Aug 5, 1999·Journal of the National Cancer Institute·UNKNOWN Breast Cancer Linkage Consortium
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·B H SpainI M Verma
Mar 10, 2001·Molecular Cell·M E MoynahanM Jasin
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·F XiaS N Powell
Jul 13, 2002·Journal of Medical Genetics·H TuliniusJ E Eyfjord
Jun 3, 2005·Cancer Research·Xin-xia TianQingshen Gao
Jun 15, 2007·Journal of the National Cancer Institute·Laufey TryggvadóttirHrafn Tulinius
Nov 7, 2007·European Urology·Joost L Boormans, Fritz H Schröder
May 29, 2008·Journal of the National Cancer Institute·Sunita R SetlurMark A Rubin
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elena López-KnowlesSandra A O'Toole
Aug 26, 2010·British Journal of Cancer·S M EdwardsUNKNOWN UK Genetic Prostate Cancer Study Collaborators and BAUS Section of Oncology
Feb 2, 2011·The Journal of Cell Biology·Elisabeth D CoeneDavid J Vaux
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn L PenneyLorelei A Mucci
Sep 29, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sabina DavidssonJennifer R Rider
Sep 10, 2013·Nature Structural & Molecular Biology·Anand D JeyasekharanAshok R Venkitaraman

❮ Previous
Next ❯

Citations

Nov 28, 2018·Melanoma Research·Helena C SarubiLuiz De Marco
Jul 6, 2017·Scientific Reports·Cathleen NientiedtStefan Duensing

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Preet K DhillonLorelei A Mucci
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Haojie LiDaniel J George
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Alcides ChauxGeorge J Netto
© 2022 Meta ULC. All rights reserved