PMID: 326818Jun 1, 1977Paper

Intracellular lysozyme and lactoferrin in myeloproliferative disorders

Journal of Clinical Pathology
D Y Mason

Abstract

Samples from 49 cases of myeloproliferative diseases were tested by an immunocytochemical technique for leucocyte lysozyme and lactoferrin. The presence of these constituents in myeloid precursors from cases of acute and chronic myeloid leukaemia reflected the degree of cellular maturation, lysozyme appearing (as it does in normal myeloid cells) at the stage of primary granule production (in promyelocytes), while lactoferrin wad detectable only in more mature, secondary granule-containing myeloid cells. Auer rods stained positively for lysozyme, in keeping with their relationship to primary granules. Monocytes from five cases of leukaemia showing predominantly monocytic differentiation were indistinguishable from normal monocytes in their staining reactions for lysozyme despite the presence of raised serum and urinary lysozyme levels. In four cases of acute myeloid leukaemia circulating polymorphs deficient in lactoferrin were detected: in one of these cases a similar percentage of polymorphs was lysozyme negative.

References

Jul 1, 1975·British Journal of Haematology·C G GearyD A Galton
Jan 1, 1975·British Journal of Haematology·D F Bainton
Nov 1, 1975·British Journal of Haematology·D Y MasonC R Taylor
Sep 1, 1967·British Journal of Haematology·A J Salsbury
Jan 1, 1972·Scandinavian Journal of Haematology·D CatovskyJ Robinson
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Jun 1, 1971·British Journal of Haematology·H AsamerH Braunsteiner
Sep 30, 1971·The New England Journal of Medicine·A T DavisP G Quie

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Citations

Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Barresi, G Tuccari
Apr 6, 1988·Journal of Immunological Methods·T W ButlerJ C Barton
Oct 1, 1978·The Journal of Experimental Medicine·H E BroxmeyerM de Sousa
May 1, 1995·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·H C Mutasa
Jan 1, 1982·Journal of Oral Pathology·J CaselitzT Jaup
Feb 1, 1986·American Journal of Surgery·C G Ward
May 1, 1979·Scandinavian Journal of Haematology·I OlssonA Gustavsson

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