Intracellular magnesium depletion relates to increased urinary magnesium loss in type I diabetes

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
A GürlekN Ozaltin

Abstract

We investigated whether erythrocyte magnesium (Mg) depletion exists in subjects with Type I diabetes. To this end, Mg levels in plasma, erythrocytes and urine were determined in 12 patients with Type I diabetes and compared with 12 healthy control subjects. Mean plasma Mg concentrations were comparable between diabetic patients and control subjects (0.90 +/- 0.29 mmol/l vs 1.04 +/- 0.14 mmol/l, respectively; p = 0.16). Mean erythrocyte Mg concentration was significantly lower in the diabetic group compared with the control group (1.41 +/- 0.56 mmol/l vs. 2.94 +/- 1.13 mmol/l, respectively; p < 0.0001). Mean urine Mg excretion was significantly elevated in the diabetic group with respect to the controls (6.86 +/- 3.5 mmol/g creatinine/24 h vs. 4.03 +/- 1.65 mmol/g creatinine/24 h, respectively; p = 0.02). As to the diabetic group, erythrocyte Mg concentration showed a significant inverse correlation with urine Mg excretion (r = -0.58, p = 0.049). There was no correlation between urine Mg concentration and glycosylated hemoglobin or fasting plasma glucose level. The data suggest that intracellular Mg depletion without significant hypomagnesemia is related to increased urinary Mg loss in patients with Type I diabetes. The urinary ...Continue Reading

Citations

Dec 29, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·L E BassoR Delport
Sep 3, 2002·Life Sciences·Pietro DelvaAlessandro Lechi
Jan 23, 2003·Molecular Aspects of Medicine·Pietro Delva
Mar 22, 2000·Clinical Chemistry and Laboratory Medicine : CCLM·G T SandersR Sanders
Aug 17, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Mehmet Emre AtabekOzgur Pirgon
Jan 1, 2011·Diabetes & Metabolic Syndrome·Poonam AgrawalPragna B Dolia
Jul 5, 2008·The British Journal of Nutrition·Maurice J Arnaud
Jan 1, 2009·Journal of Basic and Clinical Physiology and Pharmacology·G BjelakovicJ Basic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.