Intracellular mechanics and activity of breast cancer cells correlate with metastatic potential

Cell Biochemistry and Biophysics
Naama Gal, Daphne Weihs

Abstract

Mechanics of cancer cells are directly linked to their metastatic potential, or ability to produce a secondary tumor at a distant site. Metastatic cells survive in the circulatory system in a non-adherent state, and can squeeze through barriers in the body. Such considerable structural changes in cells rely on rapid remodeling of internal structure and mechanics. While external mechanical measurements have demonstrated enhanced pliability of cancer cells with increased metastatic potential, little is known about dynamics of their interior and we expect that to change significantly in metastatic cells. We perform a comparative study, using particle-tracking to evaluate the intracellular mechanics of living epithelial breast cells with varying invasiveness. Particles in all examined cell lines exhibit super-diffusion with a scaling exponent of 1.4 at short lag times, likely related to active transport by fluctuating microtubules and their associated molecular motors. Specifics of probe-particle transport differ between the cell types, depending on the cytoskeleton network-structure and interactions with it. Our study shows that the internal microenvironment of the highly metastatic cells evaluated here is more pliable and their c...Continue Reading

References

Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·M J Saxton, K Jacobson
Mar 29, 2000·Biophysical Journal·S YamadaS C Kuo
Jan 3, 2001·Physical Review Letters·A CaspiM Elbaum
Sep 5, 2001·Physical Review Letters·R LipowskyT M Nieuwenhuizen
Sep 21, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Avi CaspiMichael Elbaum
Nov 13, 2003·Physical Review Letters·A W C LauT C Lubensky
Aug 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Joseph SniderSteven P Gross
Nov 10, 2004·Biophysical Journal·Thierry Savin, Patrick S Doyle
Jun 7, 2005·Nature Materials·Predrag BursacJeffrey J Fredberg
Sep 20, 2005·Cancer Cell·Matthew J PaszekValerie M Weaver
Nov 19, 2005·Science·Dennis E DischerYu-Li Wang
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kristine D GirardDouglas N Robinson
Feb 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Steven S AnJeffrey J Fredberg
Jun 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Brenton D HoffmanJohn C Crocker
Sep 12, 2006·Biophysical Journal·Daphne WeihsMichael A Teitell
Jan 20, 2007·Science·Daisuke MizunoF C Mackintosh
Mar 24, 2007·Nanomedicine : Nanotechnology, Biology, and Medicine·Andrew E PellingJames K Gimzewski
Jun 2, 2007·Acta Biomaterialia·Subra Suresh
Aug 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Carina RaupachBen Fabry
Jun 4, 2008·Physical Review Letters·Clifford P BrangwynneDavid A Weitz
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Igor M KulicVladimir I Gelfand
Jul 26, 2008·Nature Nanotechnology·Sarah E CrossJames K Gimzewski
Jul 29, 2008·Biochemical and Biophysical Research Communications·Q S LiC T Lim
Sep 4, 2008·Physical Review Letters·Claire Wilhelm
Dec 31, 2008·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Aviv KahanaRony Granek
Dec 31, 2008·Physical Review Letters·Delphine ArcizetDoris Heinrich
Jan 21, 2009·Cancer Metastasis Reviews·Sanjay Kumar, Valerie M Weaver
Apr 30, 2009·Annual Review of Biomedical Engineering·Brenton D Hoffman, John C Crocker
Jun 13, 2009·Physical Review Letters·Vincent PelletierMaria L Kilfoil
Aug 8, 2009·Physical Review Letters·I BronsteinY Garini
Aug 25, 2009·Trends in Cell Biology·Clifford P BrangwynneDavid A Weitz
Jan 12, 2010·Journal of Biomedical Optics·Yixuan LiMichael H G Duits
Apr 7, 2010·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Naama Gal, Daphne Weihs
Dec 22, 2010·Journal of Cell Science·Paul A Janmey, R Tyler Miller
Jan 5, 2011·Physical Chemistry Chemical Physics : PCCP·Stas BurovEli Barkai
Jun 28, 2011·Nature Reviews. Cancer·Denis WirtzPeter C Searson
Aug 3, 2011·Cell Biochemistry and Biophysics·Maayan Lia Yizraeli, Daphne Weihs

❮ Previous
Next ❯

Citations

Dec 29, 2012·Annals of Biomedical Engineering·Erika J FongMuhammad H Zaman
Mar 8, 2016·Journal of Biomechanics·Feng Wei YangAnotida Madzvamuse
Feb 4, 2016·Biophysical Journal·Elena F KosloverJulie A Theriot
May 2, 2015·Biomechanics and Modeling in Mechanobiology·Amanda M SmelserGeorge Holzwarth
Jun 30, 2015·Biochimica Et Biophysica Acta·Paul HeineJosef Käs
Apr 14, 2016·Ultrasound in Medicine & Biology·Aharon AzaguryJoseph Kost
Nov 10, 2015·Journal of Biomechanics·Amit Gefen, Daphne Weihs
Jun 25, 2016·Medical Engineering & Physics·Shada Abuhattum, Daphne Weihs
Aug 18, 2016·Cytoskeleton·Valeria PanzettaSabato Fusco
Sep 21, 2016·European Biophysics Journal : EBJ·Carmela Rianna, Manfred Radmacher
Mar 5, 2013·Computer Methods in Biomechanics and Biomedical Engineering·Shada Abuhattoum, Daphne Weihs
Dec 23, 2016·Biomechanics and Modeling in Mechanobiology·Sonbula Massalha, Daphne Weihs
Feb 28, 2017·Soft Matter·Hans Vandebroek, Carlo Vanderzande
Mar 1, 2017·Biology of the Cell·Charlotte AlibertJean-Baptiste Manneville
Feb 23, 2017·Annals of Biomedical Engineering·Yulia Merkher, Daphne Weihs
Mar 20, 2018·The Journal of Biological Chemistry·Hoku West-FoyleDouglas N Robinson
Apr 28, 2018·Journal of Molecular Recognition : JMR·Prem Kumar Viji BabuManfred Radmacher
Nov 5, 2016·Journal of Biomechanical Engineering·Marianne LintzCynthia A Reinhart-King
Dec 30, 2014·Cellular and Molecular Bioengineering·Alexandre J S RibeiroKris Noel Dahl
Jul 24, 2020·International Journal of Cancer. Journal International Du Cancer·Tamar Barenholz-CohenDaphne Weihs
Jan 1, 2014·Nanobiomedicine·Mustafa UnalUmut A Gurkan
Apr 20, 2019·Physical Review. E·Roman Golkov, Yair Shokef
Nov 5, 2020·Annals of Biomedical Engineering·Martha B Alvarez-ElizondoDaphne Weihs
Mar 26, 2021·Biomicrofluidics·P M GraybillR Mirzaeifar
Jun 9, 2021·Biomaterials·Charlotte AlibertJean-Baptiste Manneville
Jun 14, 2021·Biomechanics and Modeling in Mechanobiology·Sally KortamDaphne Weihs
Feb 20, 2018·ACS Biomaterials Science & Engineering·Andrea MalandrinoEmad Moeendarbary
Aug 14, 2018·The Journal of Physical Chemistry. B·E CarlonC Vanderzande

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.