PMID: 9194058May 1, 1997Paper

Intracellular mechanisms of glutaminergic and cholinergic signal transduction in the cerebral cortex

Neuroscience and Behavioral Physiology
D G SemenovM O Samoĭlov

Abstract

A complex method was used to study the effects of acetylcholine and glutamine on the dynamics of calcium and polyphosphoinositide regulatory system activities over prolonged periods of time in the mammalian cerebral cortex, after exposure to these substances in baseline conditions and in conditions of developing adaptive responses. Adaptive responses were induced by transient hypoxia with oxymetacil as an antioxidant. Agonist stimulation of choline and glutamate receptors produced prolonged calcium and phosphoinositide responses in cortical structures; these had specific characteristics after exposure to glutamate and acetylcholine. During the development of adaptive responses, these changes underwent significant modifications. The functional importance of these effects is discussed.

References

Jun 1, 1992·Current Opinion in Neurobiology·Z I Bashir, G L Collingridge
Apr 1, 1988·Trends in Neurosciences·B Gustafsson, H Wigström
Sep 30, 2004·Bulletin of Experimental Biology and Medicine·S G DagaevV B Dolgo-Saburov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.