Intracellular pathogens convert macrophages from death traps into hospitable homes

The FEBS Journal
Julien BarbierDaniel Gillet

Abstract

Infectious microorganisms must find ways to escape or counteract the immune defenses of the host during the course of infection. The innate and adaptive immune functions of a healthy host represent serious threats for the invader and most microorganisms cannot survive in this hostile environment. One strategy to achieve such escape that is shared by many pathogenic bacteria, parasites and fungi is to hide into cells and turn them into welcoming refuges where they can multiply. In this context, the macrophage is a key cell to infect. This article is protected by copyright. All rights reserved.

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