PMID: 4979Mar 1, 1976

Intracellular pH of brain: alterations in acute respiratory acidosis and alkalosis

The American Journal of Physiology
A I ArieffJ DeLima

Abstract

To evaluate the metabolic adaptations of the brain to acute respiratory acid-base disturbances, a method was developed to measure intracellular pH (pHi) in the brain of dogs under conditions in which arterial pH is rapidly altered. Brain pHi was determined by measuring the distribution of 14C-labeled dimethadione (DMO) in brain relative to cortical CSF. Brain extracellular space (ECS) was evaluated as the 35SO4 = space relative to cortical CSF, and arterial Po2 was maintained at 82-110 mmHg. In normal dogs, brain (cerebral cortex) pHi was 7.05, and after 1 h of hypercapnia (arterial pH = 7.07) it fell to 6.93. However, after 3 h with arterial Pco2 maintained at 85 mmHg brain pHi was normal (7.06), and during this time brain bicarbonate had risen from 11.3 to 24.4 meq/kg H2O. These changes were not prevented by intravenous doses of acetazolamide,

Citations

Sep 1, 1978·Journal of Neurochemistry·T M SundtR A Van Dyke
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Grieb
May 1, 1984·Stroke; a Journal of Cerebral Circulation·K KobatakeA M Hakim
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Pelligrino, B K Siesjö
Apr 1, 1977·Archives internationales de physiologie et de biochimie·F Van LeuvenI Leusen
Jun 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T L Yaksh, R E Anderson
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S VorstrupO B Paulson
Aug 10, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Seth D FriedmanStephen R Dager
Aug 5, 2016·The Journal of Experimental Biology·Ryan B ShartauColin J Brauner
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R B BuxtonR H Ackerman
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A SyrotaJ C Baron
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Jun 1, 1988·Stroke; a Journal of Cerebral Circulation·H NakaiY L Yamamoto
Sep 1, 1987·The American Journal of Physiology·A I Arieff, H Graf

Related Concepts

Acid-Base Imbalance
Acute Disease
Blood Flow Velocity
Brain
Carbon Dioxide
Dimethadione
Canis familiaris
Hydrogen-Ion Concentration
Hypercapnia
Muscle

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