PMID: 9647345Jul 1, 1998Paper

Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection

Pharmaceutical Research
K Peter, J G Gambertoglio

Abstract

Dramatic reductions of viral load and increased survival have been achieved in patients infected with the Human Immunodeficiency Virus (HIV) with the introduction of combination antiretroviral therapy. Currently 11 agents including nucleoside reverse transcriptase inhibitors (RTI), non-nucleoside RTI and protease inhibitors are available for the use for treatment of HIV infection. Recent studies have demonstrated that certain combinations of these drugs are advantageous over their individual use as monotherapy with an even more sustained viral suppression. Much emphasis has therefore been put on studies evaluating the interactions of these different compounds. Especially the intracellular metabolism of nucleoside RTI has been evaluated to some extent, by both in vitro and in vivo studies. These compounds need to undergo phosphorylation to their active 5'-triphoshates involving several enzymatic steps and the nucleoside concentration in the plasma may not correlate with intracellular concentrations of active drug. It is therefore of great importance to study these drugs at an intracellular level in order to evaluate their efficacy. This review summarizes the intracellular phosphorylation of Zidovudine and other nucleoside analog...Continue Reading

Citations

Jun 8, 2001·Nucleosides, Nucleotides & Nucleic Acids·F AkebD Duval
Aug 1, 2007·Antimicrobial Agents and Chemotherapy·Patricia M FlynnUNKNOWN PACTG P1012 Team
Apr 10, 2010·Expert Opinion on Drug Safety·Nilza Nascimento GuimarãesKênya Silva Cunha
Feb 22, 2002·Cancer Investigation·Marco N HelderG J van der Zee
Mar 28, 2008·Environmental and Molecular Mutagenesis·Nilza Nascimento GuimarãesKênya Silva Cunha
Jun 22, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E P AcostaC V Fletcher
Jan 14, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Leonardo Pereira FranchiKênya Silva Cunha
Jan 20, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Max von Kleist, Wilhelm Huisinga

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