Intracellular potassium ion activity in resting and stimulated mouse pancreas and submandibular gland

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J H Poulsen, B Oakley

Abstract

Intracellular potassium ion activities (aiK+) and membrane potentials were measured with double-barrelled, potassium-specific microelectrodes in superfused mouse pancreas and submandibular gland. Stimulation with the cholinergic agonist bethanechol caused a marked decrease in aiK+ in the submandibular gland, whereas no change in aiK+ could be detected in the pancreas. This indicates that bethanechol increases the permeability of the cell membranes to potassium ions in the submandibular gland but not in the pancreas. Pancreatic acinar cells hyperpolarized promptly when the extracellular potassium ion activity was restored after a prolonged period of potassium deprivation. In comparison, the recovery of aiK+ was a slow process. This finding gives support to the view that the hyperpolarization is due to electrogenic sodium pumping.

References

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Citations

Apr 1, 1985·Pflügers Archiv : European journal of physiology·J O Dich-NielsenJ H Poulsen
Aug 1, 1983·Pflügers Archiv : European journal of physiology·J O'DohertyK L Brugge
Apr 1, 1984·Cell Calcium·R M Case
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·O H Petersen
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J K FoskettR J Turner
Jan 1, 1987·Scandinavian Journal of Gastroenterology·K KrogsgaardP Christoffersen
Nov 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·C Gluud, P Bennett
Jun 1, 1987·Histopathology·A LercheE Kirkegaard
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Feb 23, 1984·Nature·O H Petersen, Y Maruyama
Aug 1, 1989·Pflügers Archiv : European journal of physiology·M MurakamiH Watari
Aug 1, 1984·Pflügers Archiv : European journal of physiology·I NakagakiY Imai
Jan 14, 2021·American Journal of Physiology. Cell Physiology·John M PleinisAylin R Rodan
Dec 1, 1984·The American Journal of Physiology·K Zierler, R D Moore

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