Intracellular potassium ion activity in resting and stimulated mouse pancreas and submandibular gland

Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character
J H Poulsen, B Oakley

Abstract

Intracellular potassium ion activities (aiK+) and membrane potentials were measured with double-barrelled, potassium-specific microelectrodes in superfused mouse pancreas and submandibular gland. Stimulation with the cholinergic agonist bethanechol caused a marked decrease in aiK+ in the submandibular gland, whereas no change in aiK+ could be detected in the pancreas. This indicates that bethanechol increases the permeability of the cell membranes to potassium ions in the submandibular gland but not in the pancreas. Pancreatic acinar cells hyperpolarized promptly when the extracellular potassium ion activity was restored after a prolonged period of potassium deprivation. In comparison, the recovery of aiK+ was a slow process. This finding gives support to the view that the hyperpolarization is due to electrogenic sodium pumping.

References

Apr 1, 1985·Pflügers Archiv : European journal of physiology·J O Dich-NielsenJ H Poulsen
Aug 1, 1983·Pflügers Archiv : European journal of physiology·J O'DohertyK L Brugge
Apr 1, 1984·Cell Calcium·R M Case
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·O H Petersen
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J K FoskettR J Turner
Jan 1, 1987·Scandinavian Journal of Gastroenterology·K KrogsgaardP Christoffersen
Nov 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·C Gluud, P Bennett
Jun 1, 1987·Histopathology·A LercheE Kirkegaard
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·V T SavolainenP J Karhunen
Feb 23, 1984·Nature·O H Petersen, Y Maruyama
Aug 1, 1989·Pflügers Archiv : European journal of physiology·M MurakamiH Watari
Aug 1, 1984·Pflügers Archiv : European journal of physiology·I NakagakiY Imai

Citations

Jul 1, 1976·Physiological Reviews·O H Petersen
Dec 1, 1977·The Journal of Physiology·M BundgaardJ H Poulsen
Oct 1, 1977·The Journal of General Physiology·B Oakley
Aug 1, 1977·The Journal of Physiology·N Iwatsuki, O H Petersen
Jul 30, 1976·Pflügers Archiv : European journal of physiology·L P LaugesenJ H Poulsen
Jun 1, 1975·The Journal of General Physiology·C O Lee, H A Fozzard
Aug 31, 1973·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·O H Petersen
Jul 1, 1972·Physiological Reviews·R C Thomas
Jan 1, 1972·Pflügers Archiv : European journal of physiology·R N KhuriA Kalloghlian
Jul 9, 1974·Pflügers Archiv : European journal of physiology·J H Poulsen
Apr 27, 1956·The Journal of Physiology·A S BURGEN
Oct 1, 1960·The American Journal of Physiology·L H SCHNEYER, C A SCHNEYER

Related Concepts

Microelectrodes
Cholinergic Agonists
Extracellular
Membrane
Acinar Cell of Pancreas
Protoplasm
Potassium
Benign Tumor of Pancreas
Ion Transmembrane Transporter Activity
Mouse Pancreas

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.