Intracellular PRRs Activation in Targeting the Immune Response Against Fungal Infections.

Frontiers in Cellular and Infection Microbiology
Grasielle Pereira JannuzziKaren Spadari Ferreira

Abstract

The immune response against fungal infections is complex and exhibits several factors involving innate elements that participate in the interaction with the fungus. The innate immune system developed pattern recognition receptors that recognize different pathogen-associated molecular patterns present both on the surface of the fungi cell wall and on their genetic material. These receptors have the function of activating the innate immune response and regulating a subsequent adaptive immune response. Among pattern recognition receptors, the family of Toll-like receptors and C-type lectin receptors are the best described and characterized, they act directly in the recognition of pathogen-associated molecular patterns expressed on the wall of the fungus and consequently in directing the immune response. In recent years, the role of intracellular pattern recognition receptors (TLR3, TLR7, TLR8, and TLR9) has become increasingly important in the pathophysiology of some mycoses, as paracoccidioidomycosis, cryptococcosis, aspergillosis, and candidiasis. The recognition of nucleic acids performed by these receptors can be essential for the control of some fungal infections, as they can be harmful to others. Therefore, this review focus...Continue Reading

References

Dec 29, 2000·Nature·H HemmiS Akira
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L A GildeaS L Newman
Sep 14, 2001·Scandinavian Journal of Immunology·M C SouzaZ P Camargo
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela BacciLuigina Romani
May 7, 2002·The Journal of Infectious Diseases·Mihai G NeteaBart Jan Kullberg
Oct 1, 2003·The Journal of Experimental Medicine·Katherine A FitzgeraldDouglas T Golenbock
Jan 13, 2004·Nature Immunology·Eicke LatzDouglas T Golenbock
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Apr 6, 2004·Nature Immunology·Etienne MeylanJürg Tschopp
Jul 6, 2004·Immunological Reviews·Dennis M KlinmanDaniela Verthelyi
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvia BellocchioLuigina Romani
Feb 17, 2005·European Journal of Immunology·Carmelo BiondoGiuseppe Mancuso
Jan 18, 2006·Cell Death and Differentiation·T Kawai, S Akira
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
May 3, 2006·PLoS Pathogens·Robert T Wheeler, Gerald R Fink
Jun 10, 2006·Nature Reviews. Drug Discovery·Arthur M Krieg
Aug 24, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Shaun M Bowman, Stephen J Free
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc DubourdeauOumaïma Ibrahim-Granet
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Nov 15, 2006·Current Pharmaceutical Design·Mihai G NeteaBart Jan Kullberg
Feb 24, 2007·Nature Reviews. Immunology·Giorgio Trinchieri, Alan Sher
Mar 6, 2007·Seminars in Immunology·Gregory M Barton
Sep 26, 2007·Immunity·Andreas Pichlmair, Caetano Reis e Sousa
Sep 28, 2007·European Journal of Immunology·Teresa ZelanteLuigina Romani
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Verena MüllerMatthias Goebeler
Dec 15, 2007·Nature Reviews. Microbiology·Mihai G NeteaNeil A R Gow
Feb 12, 2008·Advanced Drug Delivery Reviews·Misako Matsumoto, Tsukasa Seya
Feb 16, 2008·The Journal of Infectious Diseases·A CarvalhoF Rodrigues
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandra ForsbachJörg Vollmer
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kiwamu NakamuraKazuyoshi Kawakami
Mar 12, 2008·Infection and Immunity·Zaida G Ramirez-OrtizStuart M Levitz
Oct 8, 2008·The Journal of Experimental Medicine·Karen A CavassaniSteven L Kunkel
Oct 28, 2008·Immunobiology·Frank Leo van de VeerdonkBart Jan Kullberg
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Daniel Gozalbo, Maria Luisa Gil
May 12, 2009·Nature Immunology·Giuseppe MancusoConcetta Beninati
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Flávio V LouresVera L G Calich
Aug 8, 2009·European Journal of Immunology·Florian EberleAlexander H Dalpke

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