Intracellular redox compartments: mechanisms and significances

Antioxidants & Redox Signaling
Thomas Kietzmann

Abstract

With the appearance of oxygen and the development of aerobic life on earth, reactive oxygen species (ROS) became important factors influencing a number of processes within a cell. Although initially considered unwanted and harmful by-products of a number of cellular reactions, the last decade has shown that ROS can also act as signalling molecules mediating changes in O(2) tension, as well as the response to hormones, growth factors, and mechanical or chemical stress. Different ROS-generating and ROS-degrading systems in different intracellular compartments seem to play an important role. In line with this, it appears that proteins already well known for an ROS-unrelated specific function in one compartment participate in the ROS response within another compartment. Thus, it is easy to envision that redox changes in different compartments and resulting changes in ROS levels may represent an important mechanism of intracellular communication between different cellular compartments.

References

Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Dec 26, 2001·Current Opinion in Hematology·J David Lambeth
Jan 25, 2002·IUBMB Life·T Finkel
Apr 30, 2003·Antioxidants & Redox Signaling·Regina Brigelius-FlohéKerstin Schnurr
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qing LiuThomas Kietzmann
Jul 10, 2004·Antioxidants & Redox Signaling·Elitsa Y DimovaThomas Kietzmann
May 21, 2005·Seminars in Cell & Developmental Biology·Thomas Kietzmann, Agnes Görlach
Sep 22, 2006·Antioxidants & Redox Signaling·Agnes GörlachThomas Kietzmann
Oct 17, 2008·Nature Reviews. Cancer·William G Kaelin
Dec 5, 2009·Antioxidants & Redox Signaling·Nicole BüchnerJudith Haendeler
Dec 5, 2009·Antioxidants & Redox Signaling·Vasily D AntonenkovJ Kalervo Hiltunen
Dec 5, 2009·Antioxidants & Redox Signaling·Nicolas UgarteBertrand Friguet
Dec 5, 2009·Antioxidants & Redox Signaling·Aline BachThomas Kietzmann
Dec 17, 2009·Antioxidants & Redox Signaling·Andreas PetryAgnes Görlach
Dec 19, 2009·Antioxidants & Redox Signaling·Luksana Chaiswing, Terry D Oberley
Dec 31, 2009·Antioxidants & Redox Signaling·Isabel DieboldAgnes Görlach
Dec 31, 2009·Antioxidants & Redox Signaling·Tino KurzUlf T Brunk
Mar 10, 2010·Antioxidants & Redox Signaling·Young-Mi Go, Dean P Jones

❮ Previous
Next ❯

Citations

Sep 3, 2013·Antioxidants & Redox Signaling·Manish MittalAsrar B Malik
Mar 5, 2016·Frontiers in Cell and Developmental Biology·Thomas KietzmannElitsa Y Dimova
Feb 7, 2014·Thrombosis and Haemostasis·Hendry SaragihStephan Immenschuh
May 30, 2015·Scientific Reports·Longlong ChenYueping Zhou
Feb 4, 2014·Oxidative Medicine and Cellular Longevity·Marianna GuidaAnto De Pol
Apr 11, 2014·BioMed Research International·Marianna GuidaAnto De Pol
Aug 15, 2015·Oxidative Medicine and Cellular Longevity·Tullia MaraldiAnto De Pol
Apr 17, 2015·Mediators of Inflammation·C LehmannB Holbein
Jul 2, 2021·Frontiers in Pharmacology·Cheng YangJianwen Liao

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPase

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.