Oct 1, 1977

Intracellular reduction of the cupric ion of bleomycin copper complex and transfer of the cuprous ion to a cellular protein

The Journal of Antibiotics
K TakahashiH Umezawa

Abstract

The cupric ion of the bleomycin copper complex has been shown to be reduced and transferred to a cellular protein by the following mechanism: Bleomycin approximately Cu2+ leads to Bleomycin plus Cu+ X Cu+ plus M leads to M approximately Cu+. The intracellular reducing agents (X) are suggested to be sulfhydryl compounds, because their action is inhibited by N-ethylmaleimide. The active group of the cellular protein (M) that binds with the cuprous ion is suggested to be a sulfhydryl group. The action of the bleomycin copper complex in causing DNA fragmentation in cells can be explained by the mechanism presented in this paper. This mechanism in cells is also supported by the temperature dependency of the action of the bleomycin copper complex on cells.

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Mentioned in this Paper

Ethylmaleimide
DNA Fragmentation
Protoplasm
Sulfhydryl Compounds
Bleomycin
Plasma Protein Binding Capacity
Copper
Binding (Molecular Function)
Oxidation-Reduction
Cytoplasmic Matrix

About this Paper

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