PMID: 9420290Jan 7, 1998Paper

Intracellular route of canine parvovirus entry

Journal of Virology
M Vihinen-RantaM Vuento

Abstract

The present study was designed to investigate the endocytic pathway involved in canine parvovirus (CPV) infection. Reduced temperature (18 degrees C) or the microtubule-depolymerizing drug nocodazole was found to inhibit productive infection of canine A72 cells by CPV and caused CPV to be retained in cytoplasmic vesicles as indicated by immunofluorescence microscopy. Consistent with previously published results, these data indicate that CPV enters a host cell via an endocytic route and further suggest that microtubule-dependent delivery of CPV to late endosomes is required for productive infection. Cytoplasmic microinjection of CPV particles was used to circumvent the endocytosis and membrane fusion steps in the entry process. Microinjection experiments showed that CPV particles which were injected directly into the cytoplasm, thus avoiding the endocytic pathway, were unable to initiate progeny virus production. CPV treated at pH 5.0 prior to microinjection was unable to initiate virus production, showing that factors of the endocytic route other than low pH are necessary for the initiation of infection by CPV.

References

May 1, 1992·Journal of Virology·R J Rigg, H Schaller
Feb 1, 1992·Virology·S Basak, H Turner
Nov 1, 1991·Journal of Virology·M J VargaE Everitt
Jan 1, 1989·Advances in Virus Research·M Marsh, A Helenius
Dec 1, 1989·The Journal of Cell Biology·J KartenbeckA Helenius
Jan 1, 1989·Annual Review of Cell Biology·J Gruenberg, K E Howell
Jan 1, 1988·Journal of Virology·A P ReedT J Miller
May 1, 1987·Virology·C NeubauerD Blaas
Jan 1, 1987·Advances in Virus Research·S F Cotmore, P Tattersall
Jun 14, 1967·Journal of Molecular Biology·B Hirt
Feb 15, 1984·The Biochemical Journal·M Marsh
Sep 1, 1982·The Journal of General Virology·P R ParadisoI I Singer
Sep 1, 1994·The Biochemical Journal·M LanzreinC Kempf
Jun 1, 1994·Journal of Virology·E PrchlaR Fuchs
Dec 1, 1993·The Journal of Cell Biology·F AnientoJ Gruenberg
Aug 1, 1993·Journal of Virology·L Pérez, L Carrasco
Jan 1, 1996·Archives of Virology·M Vihinen-RantaM Vuento

❮ Previous
Next ❯

Citations

Jan 19, 1999·Annual Review of Microbiology·H Kasamatsu, A Nakanishi
Oct 14, 2000·Annual Review of Cell and Developmental Biology·G R WhittakerA Helenius
Apr 5, 2002·Journal of Virology·Sanna SuikkanenMatti Vuento
May 4, 2010·PLoS Neglected Tropical Diseases·Claudia BönschCarlos Ros
Mar 24, 2020·Critical Reviews in Microbiology·Xiaofeng DaiLevon Abrahamyan
Mar 25, 2016·Journal of Virology·Raphael WolfisbergCarlos Ros
Apr 15, 2005·Gene Therapy·W DingJ F Engelhardt
Sep 1, 2015·Archives of Virology·Pei ZhouShoujun Li
Jun 26, 2009·Expert Opinion on Drug Delivery·E H Chowdhury
Aug 21, 2002·Journal of Virology·Amanda D StuartT D K Brown
Sep 13, 2003·Journal of Virology·Sanna SuikkanenMaija Vihinen-Ranta
Nov 22, 2019·Journal of Virology·Elina MäntyläMaija Vihinen-Ranta
Oct 5, 2017·Viruses·Elina MäntyläMaija Vihinen-Ranta
Jan 20, 2018·Scientific Reports·Elina MäntyläMaija Vihinen-Ranta
Oct 13, 2006·The Journal of General Virology·Sarah CohenNelly Panté
Oct 27, 2017·Viruses·Carlos RosJosé M Almendral
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Robert P. Stidwill, Urs F. Greber
Dec 3, 2003·Virology·Sanna SuikkanenMatti Vuento
Nov 13, 2001·Developmental Cell·Z ZádoriP Tijssen
Jul 6, 2021·Frontiers in Microbiology·Liting ShaoJianming Qiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.