Intracellular singlet oxygen photosensitizers: on the road to solving the problems of sensitizer degradation, bleaching and relocalization

Integrative Biology : Quantitative Biosciences From Nano to Macro
Elsa F F da SilvaPeter R Ogilby

Abstract

Selected singlet oxygen photosensitizers have been examined from the perspective of obtaining a molecule that is sufficiently stable under conditions currently employed to study singlet oxygen behavior in single mammalian cells. Reasonable predictions about intracellular sensitizer stability can be made based on solution phase experiments that approximate the intracellular environment (e.g., solutions containing proteins). Nevertheless, attempts to construct a stable sensitizer based solely on the expected reactivity of a given functional group with singlet oxygen are generally not sufficient for experiments in cells; it is difficult to construct a suitable chromophore that is impervious to all of the secondary and/or competing degradative processes that are present in the intracellular environment. On the other hand, prospects are reasonably positive when one considers the use of a sensitizer encapsulated in a specific protein; the local environment of the chromophore is controlled, degradation as a consequence of bimolecular reactions can be mitigated, and genetic engineering can be used to localize the encapsulated sensitizer in a given cellular domain. Also, the option of directly exciting oxygen in sensitizer-free experime...Continue Reading

References

Mar 13, 1992·Journal of Photochemistry and Photobiology. B, Biology·A RückH Schneckenburger
Nov 1, 1991·Photochemistry and Photobiology·C S Foote
Jun 1, 1974·Photochemistry and Photobiology·P Walrant, R Santus
Aug 16, 1996·Science·J R SheatsA Stocking
Jun 1, 1996·Bioorganic & Medicinal Chemistry·A W JensenD I Schuster
Mar 29, 2000·Biophysical Journal·G H Patterson, D W Piston
Apr 1, 2003·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lars-Oliver KlotzHelmut Sies
Oct 16, 2003·Journal of the American Chemical Society·Yoko YamakoshiTetsuo Nagano
Jan 27, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Michael J Davies
Mar 12, 2004·Organic Letters·Babu Rao RenikuntlaBruce A Armitage
Jan 6, 2005·Journal of the American Chemical Society·Peter K FrederiksenPeter R Ogilby
Feb 12, 2005·The Journal of Organic Chemistry·Sean P McIlroyPeter R Ogilby
Oct 26, 2005·Chemistry & Biology·George P TegosMichael R Hamblin
Apr 29, 2006·Photochemistry and Photobiology·Martin J PatersonPeter R Ogilby
May 19, 2006·Photochemistry and Photobiology·Esben SkovsenPeter R Ogilby
Jul 21, 2006·The Journal of Physical Chemistry. B·Esben SkovsenPeter R Ogilby
Sep 21, 2006·Physical Chemistry Chemical Physics : PCCP·John W SnyderPeter R Ogilby
Oct 5, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sonja HatzPeter R Ogilby
Jun 21, 2008·Chemical Communications : Chem Comm·C M Simon YauHarry L Anderson
Jan 9, 2009·Journal of the American Chemical Society·Marina K KuimovaPeter R Ogilby
Mar 27, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Robert GerdesSergiu M Gorun
Apr 2, 2009·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Thomas BreitenbachPeter R Ogilby
Jun 11, 2009·Journal of the American Chemical Society·Marina K KuimovaPeter R Ogilby
Sep 9, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·María González-BéjarJ C Scaiano
Sep 10, 2009·Journal of the American Chemical Society·Nathaniel I ShankBruce A Armitage
Feb 9, 2010·Acta histochemica·Marco AlvarezJuan C Stockert
Jun 24, 2010·Chemical Society Reviews·Peter R Ogilby
Nov 18, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·David Phillips
Jan 29, 2011·Photochemistry and Photobiology·Anita GollmerPeter R Ogilby
Apr 1, 2009·Nature Chemistry·Marina K KuimovaPeter R Ogilby

❮ Previous
Next ❯

Citations

Apr 14, 2016·Journal of Medicinal Chemistry·Ana C S LoboLuis G Arnaut
Nov 18, 2016·Nature Communications·Erin D AndersonMartin J Schnermann
Jul 26, 2018·The Journal of General Physiology·Vinay IdikudaLei Zhou
Aug 11, 2020·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·A BelanovaP Zolotukhin
Sep 28, 2017·Scientific Reports·Frederico M PimentaArnaud Gautier
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alicia BeltránFrancisco Galindo
Feb 10, 2018·Free Radical Biology & Medicine·Adam J TrewinAndrew P Wojtovich
Feb 14, 2019·The Journal of Physical Chemistry. a·Mikkel BregnhøjPeter R Ogilby

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Chemical Society
Rasmus L JensenPeter R Ogilby
Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Shin-ya TakizawaPeter R Ogilby
Physical Chemistry Chemical Physics : PCCP
John W SnyderPeter R Ogilby
© 2022 Meta ULC. All rights reserved