PMID: 7132237Aug 16, 1982

Intracellular sodium and calcium in essential hypertension

Klinische Wochenschrift
W ZidekH Vetter

Abstract

Intracellular sodium and calcium activities were measured by ion-selective electrodes in red blood cells of primary hypertensives and of normotensives with and without a familial disposition to hypertension. Intraerythrocytic sodium activity was markedly elevated in patients and normotensives with a familial disposition to hypertension (15.16 +/- 2.35 mmol/l in hypertensives and 9.74 +/- 1.43 mmol/l in normotensives, respectively, mean value +/- SD) as compared to the corresponding group without such a history (8.35 +/- 2.08 mmol/l in hypertensives and 7.00 +/- 1.38 mmol/l in normotensives). Mean intraerythrocytic calcium activity showed the highest values in patients with hypertension (32.8 +/- 32.5 mumol/l in patients with and 25.3 +/- 19.0 mumol/l in those without a familial disposition to hypertension), whereas in normotensives mean calcium activity was much lower (9.6 +/- 9.7 and 4.8 +/- 4.5 mumol/l, respectively). Our results document that a disturbed intraerythrocytic sodium metabolism is limited to patients with essential hypertension and a familial disposition to hypertension and, to a lesser extent, to normotensives showing a familial disposition to hypertension. Thus, a genetically determined alteration in intracellu...Continue Reading

References

Oct 1, 1979·European Journal of Clinical Investigation·A F Aderounmu, L A Salako
Dec 1, 1979·Clinical Science·E AmbrosioniB Magnani
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W ZidekH Vetter
Apr 3, 1980·The New England Journal of Medicine·M CanessaD C Tosteson
Apr 15, 1960·Klinische Wochenschrift·H LosseF WESSELS

Citations

Aug 15, 1983·Klinische Wochenschrift·P BaumgartH Vetter
Feb 16, 1987·Klinische Wochenschrift·W Zidek, H Vetter
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W ZidekH Vetter
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W ZidekH Vetter
Feb 15, 1988·Experientia·F R Bühler, T J Resink
Feb 15, 1988·Experientia·A RemmalP Marche
Jan 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·K SudhakarP P Reddy
Apr 26, 1984·The New England Journal of Medicine·P ErneF R Bühler
Jan 1, 1993·Fundamental & Clinical Pharmacology·J Zicha
Nov 28, 2012·North American Journal of Medical Sciences·Mohammed Abdul Hannan HazariVontela Devender Reddy
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·C SpiekerD Heck
Jan 1, 1996·Clinical and Experimental Hypertension : CHE·A B ErkiliçC Oğütman
Oct 5, 1988·The American Journal of Cardiology·A M Shepherd
Mar 1, 1987·Hypertension·R S CooperS Katz
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·P W de Leeuw, W H Birkenhäger
Jul 1, 1983·Klinische Wochenschrift·A HeidlandR M Schäfer
Jan 1, 1988·Acta Medica Scandinavica·G Ronquist, G Frithz

Related Concepts

Calcium
Disease Susceptibility
Erythrocytes
Hypertensive Disease
Sodium

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