PMID: 7009793Jan 1, 1981Paper

Intracellular spiral inclusions in cerebral cell processes in Creutzfeldt-Jakob disease

Journal of Neuropathology and Experimental Neurology
J M Reyes, E M Hoenig

Abstract

Electron microscopic examination of brain biopsy specimens from two patients with Creutzfeldt-Jakob disease revealed the presence of intracellular membranous spiral inclusions in the processes of cortical cells. These inclusions, 375 nm to 660 nm in length and 50 nm to 88 nm in width, resemble similar structures reported in a patient with the same disease by Bastian and, more recently, in a second patient by Gray et al. These inclusions bear close morphologic resemblance to spiroplasma organisms, a wall-free prokaryote known to cause a "slow-virus"-like disorder in mice.

Citations

Jan 1, 1986·Acta Neuropathologica·J H Kim, E E Manuelidis
Jan 5, 2006·Journal of Clinical Microbiology·Irina AlexeevaRobert G Rohwer
Mar 1, 1986·Neuropathology and Applied Neurobiology·E G Gray
Mar 1, 2015·Histochemistry and Cell Biology·Rocío SarasaMarta Monzón
Jan 17, 2019·Human Molecular Genetics·Alberto MalerbaCapucine Trollet

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