Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance

Journal of Drug Targeting
Min LiuHongxuan He

Abstract

The main objective of this study was to design a suitable drug delivery system for 10-hydroxycamptothecin (HCPT). In this study, HCPT-loaded solid lipid nanoparticle (HCPT-loaded SLN) was successfully prepared. The HCPT-loaded SLN was characterized by size, entrapment efficiency and drug release manner. The cytotoxicity of HCPT-loaded SLN was assessed in vitro using HepG2/HCPT cells and in vivo utilizing human tumor xenograft nude mouse model. HCPT-loaded SLN indicated the ability to target HepG2/HCPT cells and accumulated higher drug content in HepG2/HCPT cells. HCPT-loaded SLN enhanced the cytotoxicity of HCPT in a concentration-dependent manner. Based on these results, HCPT-loaded SLN suggested being a promising vehicle for liver-targeted drug delivery. Moreover, it can be of clinical interest to overcome multidrug resistance (MDR) effectively.

References

Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J O'Leary, F M Muggia
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R H MüllerS Gohla
Jun 13, 2002·Il Farmaco·E TeodoriF Gualtieri
Jan 22, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Byung-Do KimHoo-Kyun Choi
Apr 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Leyang ZhangBaorui Liu
May 29, 2007·Advanced Drug Delivery Reviews·Ho Lun WongXiao Yu Wu
Jul 15, 2009·Biochimica Et Biophysica Acta·Shyh-Dar Li, Leaf Huang
Nov 26, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wei HuChenghua Lou
May 17, 2011·Advanced Drug Delivery Reviews·Yinghuan LiJessie L-S Au
Feb 23, 2012·Journal of Materials Science. Materials in Medicine·Didi ChenHongxuan He
Nov 1, 2012·Journal of Young Pharmacists : JYP·K Priyanka, A Abdul Hasan Sathali
May 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Oleh TaratulaTamara Minko
Jul 23, 2013·Computer Methods and Programs in Biomedicine·Vishwa Priya PodduturiPedro A Derosa

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Citations

Feb 6, 2020·Journal of Cellular Physiology·Gamze Guney EskilerBerrin Tunca
Feb 23, 2020·Frontiers in Pharmacology·Xiaowen CaiChuanshan Xu

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