PMID: 9175256May 1, 1997Paper

Intracellular thiol redox status affects rat cytomegalovirus infection of vascular cells

Virus Research
R C VossenM C Van Dam-Mieras

Abstract

There is increasing evidence for cytomegalovirus (CMV) induced vascular pathology during acute infection in the immunocompromised host. Inflammation is involved in such processes, which is frequently associated with increased levels of oxidative mediators and reduced anti-oxidant protection. A relation between viral infection and oxidative stress has been recognized for human immunodeficiency virus and herpes simplex virus-1 infections, but little is known in this respect for CMV infections. We investigated if there is a relation between CMV infection of vascular cells and the intracellular redox status using an in vitro rat model. We measured intracellular glutathione levels and rat CMV (RCMV) permissiveness of rat heart endothelial cell lines (RHEC), rat smooth muscle cells (RSMC), and compared these with fully CMV-permissive rat fibroblasts (REF and Rat 2). In addition, the effects of the anti-oxidant N-acetylcysteine (NAC) and the glutathione synthesis inhibitor buthionine sulfoximide (BSO) on CMV permissiveness and replication were investigated in these cell lines. Finally, we investigated infection of vascular cells under inflammatory conditions in an in vivo rat model for acute CMV infection. The results show a very high...Continue Reading

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Citations

Nov 7, 1999·Antiviral Research·C A BruggemanG Nelissen-Vrancken
Mar 30, 2016·Biogerontology·James E Turner
Oct 28, 1999·American Heart Journal·C Bruggeman
Oct 24, 2012·Biochimica Et Biophysica Acta·Devin MorrisVishwanath Venketaraman

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