Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors

Molecular Cancer Therapeutics
H ShmeedaAlberto Gabizon

Abstract

The folate receptor is overexpressed in a broad spectrum of malignant tumors and represents an attractive target for selective delivery of anticancer agents to folate receptor-expressing tumors. This study examines folate-lipid conjugates as a means of enhancing the tumor selectivity of liposome-encapsulated drugs in a mouse lymphoma model. Folate-derivatized polyethylene glycol (PEG3350)-distearoyl-phosphatidylethanolamine was post-loaded at various concentrations into the following preparations: radiolabeled PEGylated liposomes, PEGylated liposomes labeled in the aqueous compartment with dextran fluorescein, and PEGylated liposomal doxorubicin (PLD, Doxil). We incubated folate-targeted radiolabeled or fluorescent liposomes with mouse J6456 lymphoma cells up-regulated for their folate receptors (J6456-FR) to determine the optimal ligand concentration required in the lipid bilayer for liposomal cell association, and to examine whether folate-targeted liposomes are internalized by J6456-FR cells in suspension. Liposomal association with cells was quantified based on radioactivity and fluorescence-activated cell sorting analysis, and internalization was assessed by confocal fluorescence microscopy. We found an optimal ligand mola...Continue Reading

References

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C P Leamon, P S Low
Feb 15, 1995·Biochimica Et Biophysica Acta·R J Lee, P S Low
Apr 12, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guangfeng ShiRobert J Lee
Sep 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Justin M SaulRavi V Bellamkonda
Apr 20, 2004·Advanced Drug Delivery Reviews·Philip S Low, Asok C Antony
Apr 20, 2004·Advanced Drug Delivery Reviews·Aśok C Antony
Apr 20, 2004·Advanced Drug Delivery Reviews·Hala Elnakat, Manohar Ratnam
Apr 20, 2004·Advanced Drug Delivery Reviews·Christopher P Leamon, Joseph A Reddy
Apr 20, 2004·Advanced Drug Delivery Reviews·Alberto GabizonSamuel Zalipsky
Apr 20, 2004·Advanced Drug Delivery Reviews·Xiaobin B Zhao, Robert J Lee
Jun 3, 2004·Methods in Enzymology·Stacy M StephensonRobert J Lee
Apr 28, 2005·Current Pharmaceutical Biotechnology·J A ReddyC P Leamon

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Citations

Sep 26, 2009·Cancer Chemotherapy and Pharmacology·Alberto GabizonSamuel Zalipsky
Oct 1, 2008·Histochemistry and Cell Biology·Paul Debbage, Werner Jaschke
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tamer A ElBayoumi, Vladimir P Torchilin
Feb 26, 2010·Blood·Weihsu C ChenJames C Paulson
Jan 1, 2009·Critical Reviews in Therapeutic Drug Carrier Systems·Anu PuriRobert Blumenthal
May 21, 2008·International Journal of Nanomedicine·Jörg HuwylerStephan Krähenbuhl
Mar 10, 2012·International Journal of Nanomedicine·Ramya RanganathanGanesh Venkatraman
Jun 7, 2014·International Journal of Nanomedicine·Hayley NehoffKhaled Greish
Sep 6, 2006·Journal of Liposome Research·Alberto A GabizonSamuel Zalipsky
Aug 21, 2013·Expert Opinion on Therapeutic Patents·José L Arias
Mar 31, 2009·Expert Opinion on Drug Delivery·Manasi DasSanjeeb K Sahoo
Apr 7, 2010·Journal of Drug Targeting·Sumanta Kumar SahuPanchanan Pramanik
Aug 12, 2009·Expert Opinion on Drug Delivery·Jair BarAmir Onn
Jan 26, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yogita PatilAlberto Gabizon
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sangbin LeeYu-Kyoung Oh
Jun 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sok Bee LimHayat Önyüksel
Aug 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna BershteynDarrell J Irvine
Dec 24, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Subin XiongRobert J Lee
Nov 4, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sónia DuarteMaria C Pedroso de Lima
May 18, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Chan ZhangZhang Chen
Oct 29, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amr S Abu LilaHiroshi Kiwada
Oct 9, 2008·Advanced Drug Delivery Reviews·James D ByrneLisa Brannon-Peppas
Jan 15, 2008·Urologic Oncology·Frank AlexisOmid C Farokhzad
Mar 19, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Gianfranco PasutOddone Schiavon
Oct 12, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·J E SchroederA Gabizon
Aug 25, 2007·Biomaterials·Arnaud BéduneauJean-Pierre Benoit
Sep 28, 2010·Journal of Biomedical Materials Research. Part a·M Dolores BlancoJosé M Teijón
Jan 28, 2014·Advanced Healthcare Materials·Cheng S JinGang Zheng
Apr 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna ScomparinRonit Satchi-Fainaro
Oct 15, 2013·Advanced Drug Delivery Reviews·Numfon KhemthongcharoenWibool Piyawattanametha
Jan 16, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tatsiana MironavaBasil Rigas
Jul 10, 2014·Journal of Cancer Research and Clinical Oncology·Remon BazakTamer Refaat
Jul 2, 2016·Pharmacological Reviews·Phatsapong YingchoncharoenDes R Richardson
May 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hilary ShmeedaAlberto Gabizon
Sep 18, 2012·Journal of Biomaterials Applications·Linlin ZhaoSo Yeon Kim
Jan 18, 2017·Journal of Receptor and Signal Transduction Research·Anshita GuptaSwarnlata Saraf
Jan 30, 2014·American Journal of Veterinary Research·Michael O ChildressDeborah W Knapp
Jun 24, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Mohsen ChianiAzim Akbarzadeh

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