Intracerebral hematoma as a complication of intrathecal methotrexate administration

Pediatric Blood & Cancer
Perran BoranSedat Oktem

Abstract

Neurotoxicity of methotrexate is a well-documented issue, but development of an intracerebral hematoma following administration of intrathecal methotrexate is an extremely rare entity. A 6-year-old male with the diagnosis of non-Hodgkin lymphoma was put on a treatment regimen, including intrathecal methotrexate. Six days following the last intrathecal methotrexate administration, the patient developed a deteriorating state of consciousness. There was no history of trauma. Coagulation studies and platelet count were normal. Magnetic resonance imaging of the brain demonstrated a large left frontoparietal hematoma. Intracerebral hematoma may be a very rare, but serious, complication of intrathecal methotrexate administration.

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Citations

Nov 4, 2008·Platelets·Bhavneesh SharmaPaul C Lee
Jul 2, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Shiro ImagamaNaoki Ishiguro

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