Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury

Stroke; a Journal of Cerebral Circulation
William J Powers

Abstract

Nontraumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35% to 52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show similar abnormalities to those that occur in patients with traumatic brain injury, thus raising the question of whether there are common mechanisms of injury shared by the 2 conditions. In both ICH and traumatic brain injury, there is an early reduction in the cerebral metabolic rate of oxygen without ischemia, mitochondrial dysfunction, and transient focal increases in regional glucose metabolism that occur after a few days. ICH and traumatic brain injury share barotrauma from pressure waves that propagate through the intracranial contents as a common mechanism of brain injury. Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provide further support for this theory of common injury mechanisms.

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Citations

Aug 13, 2011·Neurocritical Care·Hagen B HuttnerMartin Köhrmann
Apr 12, 2011·Journal of Neurosurgery·Maria ZetterlingElisabeth Ronne-Engström
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Aug 20, 2020·Stroke; a Journal of Cerebral Circulation·Sung Jun LeeSung Ho Jang
Mar 25, 2020·Cells·Shaik Ismail Mohammed ThangameeranHock-Kean Liew
Mar 26, 2020·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Chung-Chun HuangBor-Ren Huang
Sep 12, 2017·Frontiers in Human Neuroscience·Chuanyuan TaoChao You

Related Concepts

Cerebral Hemorrhage
Cerebrovascular Circulation
Temporal Region Trauma
Dysbarism
Brain
Craniocerebral Trauma
Ischemia
Metabolism
Oxygen
Poisoning/Injury

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.