Intracerebral hemorrhage: effective therapy at last?

International Journal of Stroke : Official Journal of the International Stroke Society
James C Grotta

Abstract

After decades of relative neglect, the past few years have been particularly eventful for clinical research into spontaneous intracerebral hemorrhage (ICH). Most importantly, we have seen completion of the first large randomized trial of surgical clot evacuation for supratentorial ICH, and also the first trial to demonstrate the efficacy of systemic recombinant factor 7 to stop parenchymal bleeding and prevent clinical worsening. Other important advances include new insights into risk factors, diagnostic imaging, pathophysiology of cellular injury, brain edema and blood flow, blood pressure management, aspiration of parenchymal and intraventricular clots; stem cell therapy, and outcome. Taken together, the impressive scope and progress of ongoing clinical and basic research demonstrate that there is no longer a place for nihilism in the approach to ICH.

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Citations

Jun 26, 2014·Clinical Reviews in Allergy & Immunology·Ervin Ç MingomatajGunter J Sturm
Jul 30, 2014·The Cochrane Database of Systematic Reviews·Joanna M WardlawGregory J del Zoppo
Mar 23, 2007·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·J Gölz
Jun 26, 2007·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Livia Chi-Yan LeeJeanne M Erickson

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