Intracerebral lipopolysaccharide induces neuroinflammatory change and augmented brain injury in growth-restricted neonatal rats.

Pediatric Research
Leigh R CampbellBarbara T Alexander

Abstract

Intrauterine growth restriction (IUGR) alters fetal development and is associated with neurodevelopmental abnormalities. We hypothesized that growth restriction from reduced intrauterine perfusion would predispose neonatal rats to subsequent inflammatory brain injury. In this study, IUGR was achieved by induced placental insufficiency in pregnant rats at 14 days of gestation. IUGR offspring and sham-operated control pups were subsequently injected with intracerebral lipopolysaccharide (LPS) as a model of periventricular leukomalacia (PVL). LPS similarly elevates proinflammatory cytokines in the brains of both IUGR and control rat pups. However, the chemokines cytokine-induced neutrophil chemoattractant-1 (CINC-1) and macrophage chemoattractant protein-1 (MCP-1), as well as microglia activation, were significantly higher in LPS-treated IUGR rat pups as compared with LPS-treated controls. In addition to the unique brain inflammatory response, IUGR rat pups demonstrated increased brain damage with an increased number of apoptotic cells, larger lateral ventricular size, and more severe impairment of myelination. This study provides evidence that placental insufficiency may sensitize the innate immune system in the immature brain an...Continue Reading

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Citations

Mar 31, 2012·Journal of Molecular Histology·Shaima M AlmasryFawzia A Habib
Jul 4, 2013·Acta Paediatrica·T F McElrathUNKNOWN ELGAN Study Investigators
May 8, 2013·Respiratory Physiology & Neurobiology·Anjum JafriRichard J Martin
Sep 7, 2016·Journal of Neuroinflammation·Augusto F SchmidtSuhas G Kallapur
Mar 16, 2019·Journal of Neuroscience Research·Raquel Garcia-Hernandez
Oct 20, 2017·Journal of Perinatology : Official Journal of the California Perinatal Association·J CortezM L Hudak
Oct 9, 2012·Expert Review of Neurotherapeutics·Robert K McNamara, Francis E Lotrich
Jul 23, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Da Silva-CandalF Campos
Jan 27, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carlo Romano SettanniAntonio Gasbarrini
Dec 6, 2016·Placenta·Julie A WixeyS Tracey Bjorkman
Oct 17, 2017·Pediatrics·Steven J KorzeniewskiUNKNOWN ELGAN Study Investigators

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