PMID: 16627931Apr 22, 2006Paper

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease

Journal of Alzheimer's Disease : JAD
Nataniel Lester-CollSuzanne M de la Monte

Abstract

The cascade of Alzheimer's disease (AD) neurodegeneration is associated with persistent oxidative stress, mitochondrial dysfunction, impaired energy metabolism, and activation of pro-death signaling pathways. More recently, studies with human postmortem brain tissue linked many of the characteristic molecular and pathological features of AD to reduced expression of the insulin and insulin-like growth factor (IGF) genes and their corresponding receptors. We now demonstrate using an in vivo model of intracerebral Streptozotocin (ic-STZ), that chemical depletion of insulin and IGF signaling mechanisms combined with oxidative injury is sufficient to cause AD-type neurodegeneration. The ic-STZ-injected rats did not have elevated blood glucose levels, and pancreatic architecture and insulin immunoreactivity were similar to control, yet their brains were reduced in size and exhibited neurodegeneration associated with cell loss, gliosis, and increased immunoreactivity for p53, active glycogen synthase kinase 3beta, phospho-tau, ubiquitin, and amyloid-beta. Real time quantitative RT-PCR studies demonstrated that the ic-STZ-treated brains had significantly reduced expression of genes corresponding to neurons, oligodendroglia, and choline...Continue Reading

Citations

Dec 14, 2018·Frontiers in Aging Neuroscience·Xingyu ZhangZhentao Zhang
Apr 15, 2008·Proteins·Malene Ringkjøbing JensenJens J Led
Mar 4, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruo L ChenJane E Preston
Jan 18, 2012·The Biochemical Journal·Amy R CameronGraham Rena
May 18, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Hayate JavedFakhrul Islam
Dec 18, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wenqing YangHuarong Yu
Mar 15, 2015·Experimental & Molecular Medicine·Bhumsoo Kim, Eva L Feldman
Mar 31, 2015·Oxidative Medicine and Cellular Longevity·Sergio Rosales-CorralRussel J Reiter
Jul 3, 2015·Frontiers in Neuroscience·Gaurav BedseTommaso Cassano
Jul 15, 2015·Journal of Intensive Care Medicine·F BilottaG Rosa
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Chetram DeochandSuzanne M de la Monte
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Ming TongSuzanne M de la Monte
Feb 9, 2017·Cognitive Neurodynamics·Bhagyashree NaikAnuradha Majumdar
Aug 3, 2017·Journal of Neural Transmission·Peter RiedererTali Cukierman-Yaffe
Aug 3, 2017·Molecular Brain·Juhyun SongByeong C Kim
Jun 7, 2017·Journal of Alzheimer's Disease : JAD·Warnakulasuriya M A D B FernandoRalph N Martins
May 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ali Asghar HemmatiAkram Ahangarpour
Jun 12, 2018·Physiological Reports·Bradley J BaranowskiRebecca E K MacPherson
Jan 15, 2020·Canadian Journal of Physiology and Pharmacology·Harmandeep SinghJitender Madan
Mar 17, 2020·Expert Opinion on Investigational Drugs·Christian Hölscher
Feb 8, 2020·Journal of Neural Transmission·Jelena Osmanovic BarilarMelita Salkovic-Petrisic
Jul 12, 2008·Alcoholism, Clinical and Experimental Research·Suzanne M de la MonteJack R Wands
Jun 19, 2007·Antioxidants & Redox Signaling·Masahiro OkouchiTak Yee Aw
Aug 14, 2010·Journal of Toxicology and Environmental Health. Part a·Monika Sałaga-PylakAndrzej Borzecki
Apr 22, 2009·Biogerontology·Najma Z BaquerDeepak Sharma

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