PMID: 6165431May 4, 1981Paper

Intracerebral substance P in mice: behavioral effects and narcotic agents

Brain Research
N N Share, A Rackham

Abstract

Acute intracerebral injection of the undecapeptide, substance P, in mice induced a unique reciprocal hindlimb scratching response whose intensity was dose-related. Similar intracerebral dose-response curves were obtained by the structurally related undecapeptides, physalaemin and eledoisin, but not by several unrelated peptides (TRH, neurotensin, bradykinin, somatostatin), prostaglandins E2 and F2a, dibutyryl cyclic AMP or dibutyrylcyclic GMP. Analgesic narcotic agents with predominant agonist activity administered i.p. prevented the reciprocal hindlimb scratching response induced by intracerebral substance P (0.625 microgram/mouse = ED 95). In this in vivo assay their action was stereospecific and exhibited a rank order of potency similar to that reported for analgesic activity and binding to opiate receptors in vitro. Narcotic agents with mixed agonist-antagonist activity were inactive while the narcotic antagonist, naloxone, completely reversed the action of morphine. Higher doses of naloxone alone potentiated substance P-induced reciprocal hindlimb scratching which may explain why partial narcotic agonists failed to abolish the response. There is now considerable evidence in support of a sensory neurotransmitter/modulator r...Continue Reading

Citations

Dec 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H KuwaharaE Munekata
Aug 27, 1986·Brain Research·P J Elliott, S D Iversen
Jan 28, 1983·European Journal of Pharmacology·S P WatsonL L Iversen
Nov 1, 1983·Peptides·D E Gmerek, A Cowan
Jan 2, 1986·European Journal of Biochemistry·G ChassaingS Lavielle
Aug 18, 2009·The Journal of Pharmacology and Experimental Therapeutics·Carrie L WadeCarolyn A Fairbanks
Apr 1, 1987·Pain·Mauricio De Castro-CostaJohan Van Hees

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