Intracerebral transplantation of carotid body in rats with transient middle cerebral artery occlusion

Brain Research
Guolong YuC V Borlongan

Abstract

Recent laboratory and clinical studies demonstrate therapeutic efficacy of intracerebral transplantation of carotid body (CB) in Parkinson's disease, possibly through secretion of neurotrophic factors. Here, we examined the role of CB in experimental stroke. In the first experiment, we hypothesized that removal of CB would exacerbate cerebral infarction and stroke-related behavioral deficits. Eight-week-old, male Sprague-Dawley rats were randomly divided into two groups: stroke with intact CB and stroke with surgically removed CB. We used the stroke model of temporary middle cerebral artery occlusion. The ipsilateral CB was removed in animals assigned to treatment group exposed to stroke with surgically removed CB. Behavioral tests, using the elevated body swing test, were conducted at days 1-3 after surgery. Cerebral infarction was visualized by TTC staining on day 3 post-surgery. The data revealed no significant differences in behavioral deficits and infarct volumes between the two groups. In the second experiment, CB cell suspension grafts or control adult tissue grafts were intracerebally transplanted into the ischemic penumbra immediately (within 1 h) after stroke surgery. The results revealed significant reduction of beha...Continue Reading

References

Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·M GrabowskiB B Johansson
Jan 1, 1997·Neuroscience and Biobehavioral Reviews·C V BorlonganP R Sanberg
Jun 1, 1997·Experimental Neurology·A J Okragly, M Haak-Frendscho
Nov 22, 1997·Stroke; a Journal of Cerebral Circulation·C E WalderG R Thomas
May 13, 1999·Lancet·C V BorlonganT B Freeman
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Y H ChiangY Wang
Feb 24, 2001·Neuroreport·C V Borlongan
Jun 22, 2002·Annals of the New York Academy of Sciences·Y WangJ Hoffer
Mar 11, 2003·Physical Medicine and Rehabilitation Clinics of North America·Kevin Cairns, Seth P Finklestein
Jul 18, 2003·Journal of Neuroscience Research·A E WillingP R Sanberg

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Citations

Mar 6, 2009·Journal of Neural Transmission·José López-BarneoJuan José Toledo-Aral
Jan 16, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Adolfo Mínguez-CastellanosJosé López-Barneo
Jun 30, 2012·Neurobiology of Aging·Ana B Muñoz-ManchadoJuan J Toledo-Aral
Jan 12, 2005·Neuroscience and Biobehavioral Reviews·Guolong YuCesar V Borlongan

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