Intracerebroventricular administration of galanin antagonist sustains insulin resistance in adipocytes of type 2 diabetic trained rats

Molecular and Cellular Endocrinology
Zhenwen ZhangYan Zhu

Abstract

The aim of this study is to investigate whether galanin (GAL) central receptors are involved in regulation of insulin resistance. To test it, a GAL antagonist, M35 was intracerebroventricularly administrated in trained type 2 diabetic rats. The euglycemic-hyperinsulinemic clamp test was conducted for an index of glucose infusion rates. The epididymal fat pads were processed for determination of glucose uptake and Glucose Transporter 4 (GLUT4) amounts. The Gal mRNA expression levels in hypothalamus were quantitatively assessed too. We found an inhibitory effect of M35 on glucose uptake into adipocytes, Gal mRNA expression levels in hypothalamus, glucose infusion rates in the clamp test and GLUT4 concentration in plasma membranes and total cell membranes of adipocytes. The ratios of GLUT4 contents of the former to the latter in M35 groups were lower. These results suggest a facilitating role for GAL on GLUT4 translocation and insulin sensitivity via its central receptors in rats.

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Citations

Feb 7, 2014·The Journal of Endocrinology·Le BuShen Qu
Dec 26, 2012·Clinical Biochemistry·Penghua FangZhenwen Zhang
Mar 4, 2014·Pharmacology, Biochemistry, and Behavior·Penghua FangZhenwen Zhang
Sep 23, 2014·The Journal of Endocrinology·Lili GuoZhenwen Zhang
Feb 5, 2013·Life Sciences·Penghua FangMingyi Shi
Nov 21, 2015·Experimental Gerontology·Penghua FangZhenwen Zhang
Nov 7, 2015·Neuroscience and Biobehavioral Reviews·Penghua FangZhenwen Zhang
Aug 9, 2015·Mechanisms of Ageing and Development·Zhenwen ZhangPing Bo
Aug 23, 2012·General and Comparative Endocrinology·Penghua FangPing Bo
Aug 24, 2016·Scientific Reports·Héctor Fabio Sandoval-AlzateJorge E Caminos
Feb 6, 2020·Pharmacological Reports : PR·Penghua FangZhenwen Zhang
Nov 20, 2016·Neural Regeneration Research·Xiao-Feng XuWei Qiu
Jun 27, 2020·Journal of Endocrinological Investigation·L GuoZ Zhang
Jan 9, 2019·The Journal of International Medical Research·Lei ZhangPing Bo

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