Intracerebroventricular administration of drugs

Aaron M CookJ Hatton


Intracerebroventricular drug administration is a method that bypasses the blood-brain barrier and other mechanisms that limit drug distribution into the brain, allowing high drug concentrations to enter the central compartment. Instillation of drugs directly into the ventricles of the brain must be done carefully and with full consideration of factors affecting the efficacy and safety of this route of administration. These factors include the osmolarity, pH, volume, and presence of preservatives and diluents of the drug solution being administered. Very few studies have formally investigated intraventricular therapies, and dosing recommendations may vary widely depending on the agent and the patient. Many antimicrobials have been given intraventricularly, although very few prospective studies have evaluated this strategy. There are wide variations among the reports regarding dosage regimens and the pharmacokinetics of the antimicrobials used. Guidance on appropriate formulations and their use is lacking. Clinicians should be aware of their patients' ongoing disease processes and neurologic status, as well as pertinent physiochemical properties of drugs when formulating them for intracerebroventricular administration; a high ind...Continue Reading


Dec 1, 1975·Journal of Applied Physiology·S W Bledsoe, A H Mines
Jan 1, 1979·The Journal of International Medical Research·H TrujilloA I Zuluaga
Jun 1, 1978·Antimicrobial Agents and Chemotherapy·D J Briedis, H G Robson
Mar 1, 1976·Archives of Disease in Childhood·E L LeeS D Puthucheary
Dec 11, 1975·The New England Journal of Medicine·A B Kaiser, Z A McGee
May 1, 1992·Journal of Neuro-oncology·H NakagawaT Hayakawa
Nov 1, 1988·The Journal of Infectious Diseases·C ReesorP J Jewesson
Feb 1, 1988·The Journal of Antimicrobial Chemotherapy·C L Golledge, T McKenzie
Feb 1, 1987·The Journal of Antimicrobial Chemotherapy·R SwayneS W Newsom
Jan 1, 1987·Acta neurochirurgica·E DonauerR Kivelitz
Nov 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·R BaystonM Barnicoat
Oct 1, 1974·Journal of Neurosurgery·M H WeissF E Nulsen
May 27, 1967·British Medical Journal·R L Newman, R J Holt
Jun 1, 1980·Neurosurgery·E D Everett, L J Strausbaugh
Mar 1, 1983·The Journal of Clinical Investigation·W Michael Scheld, M A Sande
Dec 1, 1981·The American Journal of Medicine·G E SutherlandS L Luedke
Jan 1, 1980·Journal of Neurosurgery·S L Wald, R L McLaurin
Jul 1, 1993·The Annals of Pharmacotherapy·M S Luer, J Hatton
Jun 1, 1993·Journal of Neurosurgery·T O Grøndahl, I A Langmoen
Jan 1, 1997·Antimicrobial Agents and Chemotherapy·A AhmedG H McCracken
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bettina PfauslerE Schmutzhard
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I LutsarI R Friedland
Apr 9, 1999·Anesthesia and Analgesia·P S HodgsonS S Liu
Aug 19, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S Segal-MaurerJ J Rahal
Aug 5, 2000·Neurosurgery·D I SandbergP H Gutin
Dec 5, 2000·Pharmacy World & Science : PWS·L F BeenenD A Haring
Dec 18, 2001·Chest·P Eggimann, D Pittet
Jan 31, 2002·The Annals of Pharmacotherapy·Pedro V Chicano-PiáEva Romá-Sánchez
Feb 23, 2002·Drug Development and Industrial Pharmacy·P R LockmanD D Allen
Aug 17, 2002·Neurosurgery·Alan P LozierE Sander Connolly
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Albertus G de BoerPieter J Gaillard
Dec 20, 2003·Neurosurgery·Edward A Neuwelt
Oct 21, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelRichard J Whitley
Feb 12, 2005·Chest·Ghassan A AlothmanAllan L Coates
Jul 19, 2005·Nature Reviews. Neuroscience·Wolfgang Löscher, Heidrun Potschka
Sep 13, 2005·Clinical Pharmacology and Therapeutics·Richard H Ho, Richard B Kim
Feb 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·George H TalbotAntimicrobial Availability Task Force of the Infectious Diseases Society of America
Apr 28, 2006·Antimicrobial Agents and Chemotherapy·Yusuf NalcaSusanne Häussler
Jun 29, 2007·Clinical Pharmacokinetics·Albertus G de Boer, Pieter J Gaillard


Apr 23, 2013·Clinical Pharmacokinetics·Antonello Di PaoloMario Del Tacca
Mar 1, 2012·Accounts of Chemical Research·Guillaume MerceyPierre-Yves Renard
Feb 15, 2013·Lab on a Chip·Ane AltunaLiset Menendez de la Prida
Jun 13, 2012·Antimicrobial Agents and Chemotherapy·Roberto ImbertiMario Regazzi
Jul 19, 2013·The Journal of Clinical Investigation·Virginia HaurigotFatima Bosch
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aaron J CarmanMargaret S Bynoe
Jan 8, 2013·Expert Opinion on Drug Delivery·Kazutaka NishinaTakanori Yokota
Nov 22, 2013·Journal of the American Pharmacists Association : JAPhA·James A Ponto, Michael M Graham
Apr 5, 2016·The Journal of Clinical Investigation·Do-Geun Kim, Margaret S Bynoe
Jul 27, 2015·Colloids and Surfaces. B, Biointerfaces·Oihane GartziandiaRosa Maria Hernandez
Sep 4, 2015·Fluids and Barriers of the CNS·Margaret S BynoeDo-Geun Kim
Apr 26, 2011·Seizure : the Journal of the British Epilepsy Association·Annelies Van DyckePaul Boon
May 20, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Maurizio ScarpaDavid J Begley
Jan 1, 2013·Rare Diseases·Virginia Haurigot, Fatima Bosch
Jul 16, 2016·Toxicon : Official Journal of the International Society on Toxinology·Jacqueline GonçalvesMárcia Mortari
Feb 7, 2017·Physical Chemistry Chemical Physics : PCCP·Arup Kumar Pathak, Tusar Bandyopadhyay
Feb 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allan R TunkelJoseph R Zunt
Mar 9, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Keaton S Smetana, Aaron M Cook
Aug 6, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jean A PatelSarah Sutton
Apr 18, 2019·Therapeutic Delivery·Hyun Joon LeeParminder Js Vig
Dec 1, 2019·Biomolecules·Yuefei ZhuZhiqing Pang
Jul 20, 2019·Experimental Brain Research·Serdar AlpdoganToni Schneider
Sep 24, 2019·Frontiers in Pharmacology·Andrew PetersonXiang-Ping Chu
Jun 8, 2018·Advanced Science·Pierpaolo MoscarielloJana Hedrich
Oct 25, 2017·Neurotoxicity Research·Magdalena Kurnik-ŁuckaKrzysztof Gil
Jun 28, 2019·International Journal of Molecular Sciences·Rana Abdul RazzakFrank J Gunn-Moore
Sep 1, 2017·Translational and Clinical Pharmacology·Arthur J Atkinson
Nov 18, 2020·Investigational New Drugs·María Belen CancelaPaula Schaiquevich
Feb 24, 2021·Physiology & Behavior·Jennifer M ErichsenJim R Fadel
Mar 12, 2021·Advanced Drug Delivery Reviews·Ghazal Naseri KouzehgaraniDidier R Lefebvre

Related Concepts

Blood - Brain Barrier Anatomy
Dose-Response Relationship, Drug
Pharmaceutical Preparations
Pharmaceutical Excipient
Injections, Intraventricular
Drug or Chemical Tissue Distribution

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.