Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin

Regulatory Peptides
G H GreeleyJ C Thompson


Intracerebroventricular (i.c.v.) administration of salmon calcitonin (500 ng) augmented glucose-stimulated release of insulin in rats. Vagotomy increased this enhancement effect of i.c.v. calcitonin significantly, whereas peripheral atropine treatment did not change it. Adrenal catecholamines did not participate in the centrally mediated insulinotropic effect of calcitonin since acute adrenalectomy did not modify the enhancement effect of i.c.v. calcitonin. Destruction of the sympathetic ganglia by neonatal treatment with 6-hydroxydopamine abolished the enhancement effect of i.c.v. calcitonin, which suggests that the sympathetic nervous system participates in the central action of calcitonin to enhance glucose-stimulated release of insulin.


Dec 1, 1979·Acta Endocrinologica·K L BeckerO L Silva
Aug 1, 1978·Metabolism: Clinical and Experimental·L CantalamessaM Peracchi
Jan 1, 1972·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R ZieglerH Minne
Jan 1, 1973·The Journal of Clinical Investigation·D PorteJ Posternak
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May 11, 1981·Life Sciences·J E Morley, A S Levine
Feb 1, 1984·The Journal of Endocrinology·B BillaudelW J Malaisse
Mar 1, 1984·Regulatory Peptides·G H Greeley, J C Thompson
Jun 1, 1983·Pharmacology, Biochemistry, and Behavior·M J TweryR B Mailman
Apr 1, 1980·Pharmacology, Biochemistry, and Behavior·M J PerlowR J Wyatt
Nov 6, 1981·Science·J E MorleyS E Silvis
Oct 5, 1981·Brain Research·A S Levine, J E Morley
Aug 4, 1980·Brain Research·K L BeckerC F Moore

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Nov 25, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·K L HullS Harvey
Oct 1, 1993·Reviews in the Neurosciences·W A Banks, A J Kastin

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