PMID: 6324949Mar 19, 1984Paper

Intracerebroventricular and preoptic injections of leukotrienes C4, D4, and E4 in the rat: lack of febrile effect

Brain Research
S T O'Rourke, T A Rudy


Experiments were performed to ascertain the effect on core temperature in the rat of central administration of 3 products of the lipoxygenase pathway of arachidonate metabolism. The agents tested were leukotrienes C4, D4, and E4 (LTC4, LTD4, LTE4). In one series of rats, the leukotrienes were injected into the ventral aspect of the third cerebral ventricle (5 microliter injection volume). Each rat received, in separate experimental sessions, an injection of a control solution, of 1 microgram of prostaglandin E1 (PGE1) and of 1 microgram of LTC4, LTD4, or LTE4. In another series of rats, bilateral 1 microliter injections into the tissue of the preoptic region were made. Each animal received a control solution, 40 ng PGE1 (20 ng/side) and 400 ng LTC4, LTD4, or LTE4 (200 ng/side). Neither the intraventricular nor the preoptic injections of any of the leukotrienes produced a significant increase in colonic temperature. However, PGE1 injected intraventricularly or into the preoptic region produced a large, rapidly developing core temperature rise. The strong febrile response to PGE1 and the results of dye distribution studies indicate that the lack of effect of the leukotrienes was not due to incorrect injection cannula placement. T...Continue Reading


Jun 15, 1979·Biochemical Pharmacology·G A HiggsJ R Vane
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Jul 1, 1967·The Journal of Physiology·K E CooperA J Honour
Oct 1, 1982·Neuropharmacology·S B Kandasamy, B A Williams
Nov 28, 1980·Science·F A Kuehl, R W Egan
Aug 1, 1982·Prostaglandins, Leukotrienes, and Medicine·M Schalin, P Uotila
Mar 1, 1981·British Journal of Pharmacology·N FeuersteinP W Ramwell
Nov 19, 1981·European Journal of Pharmacology·G FeuersteinI J Kopin
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Feb 1, 1981·Journal of Medicinal Chemistry·P Borgeat, P Sirois
Jul 1, 1981·Pharmacological Research Communications·C OminiF Berti

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