Intracerebroventricular cholecystokinin A-receptor antagonist does not reduce satiation by endogenous CCK

Physiology & Behavior
L Brenner, R C Ritter

Abstract

Suppression of sham feeding by exogenous CCK-8 or intraintestinal oleate infusion is attenuated by peripheral administration of the CCK-A receptor antagonist, devazepide, but not by the CCK-B antagonist, L365260. Likewise, systemically administered devazepide increases food intake by real feeding rats. These results suggest that endogenous CCK participates in the reduction of food intake by intestinal oleate and ingested food. Although originally categorized as a "peripheral" receptor subtype, the CCK-A receptor is also present in the brain. In an effort to examine whether devazepide acts in the brain or in the periphery to attenuate suppression of food intake by intraintestinal oleate, we injected devazepide into the lateral or fourth cerebral ventricles of intraintestinally infused, sham-fed rats. We also compared the ability of intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) devazepide to elicit increased food intake in real feeding rats. Doses of devazepide that were sufficient to attenuate or abolish oleate-induced suppression of sham feeding, when administered i.p., failed to attenuate suppression of intake when administered i.c.v., i.p. devazepide also was more effective than i.c.v. devazepide for attenuation...Continue Reading

References

Oct 1, 1987·The Journal of Pharmacy and Pharmacology·R G Pullen, O J Hodgson
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Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·L A Brenner, R C Ritter

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Citations

Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·J Ernie BlevinsRoger D Reidelberger
Feb 15, 2000·Regulatory Peptides·M CovasaR C Ritter
May 26, 2004·Physiology & Behavior·Robert C Ritter
Oct 9, 2013·Hormones and Behavior·Frank A DucaMihai Covasa
Sep 11, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bart C De JongheMihai Covasa
Jan 1, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger D ReidelbergerMartin Hulce

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