Intracochlear administration of steroids with a catheter during human cochlear implantation: a safety and feasibility study

Drug Delivery and Translational Research
Nils K PrenzlerAthanasia Warnecke

Abstract

Suppression of foreign body reaction, improvement of electrode-nerve interaction, and preservation of residual hearing are essential research topics in cochlear implantation. Intracochlear pharmaco- or cell-based therapies can open new horizons in this field. Local drug delivery strategies are desirable as higher local concentrations of agents can be realized and side effects can be minimized compared to systemic administrations. When administered locally at accessible, basal parts of the cochlea, drugs reach apical regions later and in much lower concentrations due to poor diffusion patterns in cochlear fluids. Therefore, new devices are needed to warrant rapid distribution of agents into all parts of the cochlea. Five patients received a deep intracochlear injection of triamcinolone with a specifically designed cochlear catheter during cochlear implantation right before inserting a cochlear implant electrode. As a measure for formation of fibrous tissue around the electrode, electrical impedances were measured in the operation room and over 4 months thereafter. No adverse events were observed peri- and postoperatively. The handling of the device was easy. Severe damage to the microstructure of the cochlea was excluded as far ...Continue Reading

References

May 1, 1981·Acta Oto-laryngologica·S K Juhn, L P Rybak
Mar 7, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·G PaascheT Stöver
Sep 21, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Jay T Rubinstein
Jul 27, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Bernard FraysseChris James
Jul 27, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Gerrit PaascheThomas Lenarz
Aug 4, 2006·The Laryngoscope·Jose N Fayad, Fred H Linthicum
Apr 10, 2007·Hearing Research·Darius RejaliYehoash Raphael
Apr 29, 2009·Audiology & Neuro-otology·A BüchnerT Lenarz
Apr 28, 2009·Frontiers in Neuroendocrinology·Markus Kipp, Cordian Beyer
May 5, 2009·Frontiers in Neuroendocrinology·Mélanie BourqueThérèse Di Paolo
Nov 20, 2009·Audiology & Neuro-otology·Alec N Salt, Stefan K Plontke
Aug 21, 2010·Trends in Amplification·Julie Arenberg Bierer
Jul 5, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Philip A BirdEvan J Begg
May 15, 2013·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Amandeep S GrewalVincent Y W Lin
May 18, 2013·JAMA Otolaryngology-- Head & Neck Surgery·Albert Mudry, Mara Mills
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Jan 29, 2014·Journal of the Association for Research in Otolaryngology : JARO·Dyan RamekersWilko Grolman
Dec 19, 2014·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·R Lawrence, R Thevasagayam
Mar 15, 2015·International Journal of Audiology·Carrie NewboldRichard Dowell
Sep 1, 2015·Frontiers in Cellular Neuroscience·Esperanza BasAdrien A Eshraghi
Oct 8, 2015·Otolaryngologic Clinics of North America·Joseph P Roche, Marlan R Hansen
Jan 23, 2016·Molecular Neurobiology·Pratap KarkiEunsook Lee
Feb 26, 2016·Cochlear Implants International·Jafri KuthubutheenVincent Lin
Oct 9, 2016·Stem Cell Research & Therapy·Ariane RoemerAthanasia Warnecke
Nov 30, 2016·International Journal of Immunopathology and Pharmacology·Andrea CiorbaStavros Hatzopoulos
May 4, 2017·Drug Delivery and Translational Research·Umberto M MusazziFrancesco Cilurzo
May 23, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Marco Bauzá-ThorbrüggeIsabel Lladó
Jul 7, 2017·International Archives of Otorhinolaryngology·Ahmed Khater, Mohammad Waheed El-Anwar
Jul 13, 2017·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jonathon LoStephen O'Leary

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Citations

Jul 18, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nils K PrenzlerAthanasia Warnecke
Aug 29, 2020·International Journal of Computer Assisted Radiology and Surgery·Thomas S RauThomas Lenarz
May 30, 2019·Frontiers in Cellular Neuroscience·Verena ScheperJana Schwieger
Apr 6, 2021·Acta Oto-laryngologica·Ingeborg Hochmair
May 25, 2021·Metabolomics : Official Journal of the Metabolomic Society·Michel KatherArne Liebau
Jun 3, 2021·Nanomaterials·Dan Cristian GheorgheAlexandru Mihai Grumezescu
Jun 18, 2021·Journal of Extracellular Vesicles·Athanasia WarneckeEva Rohde

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Methods Mentioned

BETA
cochlear implants
cochlear implant
pharmacotherapy
imaging techniques

Software Mentioned

OsiriX
Graph Pad Prism
Maestro
Osirix MD

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