PMID: 8984030Jun 1, 1996Paper

Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis

Gut
X BertránM A Gassull

Abstract

5-Lipoxygenase products play a part in inflammatory response. The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. Ninety rats with trinitrobenzenesulphonic acid induced colitis were randomised to receive placebo, 5-aminosalicylic acid (50 mg/kg), or zileuton (50 mg/kg) intracolonically for four weeks. Local eicosanoid release was monitored by intracolonic dialysis throughout the study. The colon was removed for macroscopic and histological assessment at weeks 1, 2, and 4 after colitis induction in 10 rats of each group. Zileuton significantly reduced macroscopic damage score after four weeks of treatment in comparison with the other two groups (p = 0.034). In addition, zileuton administration significantly increased the intracolonic release of both thromboxane B2 at week 1 (p = 0.05) and prostaglandin E2 at weeks 2 and 4 (p < 0.05). Zileuton and 5-aminosalicylic acid decreased leukotriene B4 release by 90% at day 3. Intracolonic zileuton, compared with 5-aminosalicylic acid and placebo, seems to improve the course of the disease in a model of chronic colitis. This effect may be related to an increased and mainta...Continue Reading

References

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Citations

Jan 19, 2007·Inflammatory Bowel Diseases·James JuppAnthony P Sampson
Feb 21, 2008·Inflammatory Bowel Diseases·Françoise Stanke-LabesqueBruno Bonaz
Aug 20, 2010·Inflammatory Bowel Diseases·Stephane NanceyDominique Kaiserlian
Apr 12, 2012·Mucosal Immunology·B M Fournier, C A Parkos
Jun 27, 2009·Journal of Drug Targeting·Emma L McConnellAbdul W Basit
Oct 2, 2014·Journal of Veterinary Internal Medicine·S D DumuscI A Burgener
Aug 1, 1997·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F Fernández-BañaresM A Gassull
Apr 14, 2016·Nutrients·Teresa VezzaJulio Galvez
Sep 6, 2001·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·J MañéM A Gassull
Jul 28, 2016·European Journal of Pharmacology·Giovanni PallioDomenica Altavilla
Aug 21, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Eun Mi SongHae Young Park
Apr 12, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Salvatore CuzzocreaLidia Sautebin

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