Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial

Lancet
Kai C WollertHelmut Drexler

Abstract

Emerging evidence suggests that stem cells and progenitor cells derived from bone marrow can be used to improve cardiac function in patients after acute myocardial infarction. In this randomised trial, we aimed to assess whether intracoronary transfer of autologous bone-marrow cells could improve global left-ventricular ejection fraction (LVEF) at 6 months' follow-up. After successful percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction, 60 patients were randomly assigned to either a control group (n=30) that received optimum postinfarction medical treatment, or a bone-marrow-cell group (n=30) that received optimum medical treatment and intracoronary transfer of autologous bone-marrow cells 4.8 days (SD 1.3) after PCI. Primary endpoint was global left-ventricular ejection fraction (LVEF) change from baseline to 6 months' follow-up, as determined by cardiac MRI. Image analyses were done by two investigators blinded for treatment assignment. Analysis was per protocol. Global LVEF at baseline (determined 3.5 days [SD 1.5] after PCI) was 51.3 (9.3%) in controls and 50.0 (10.0%) in the bone-marrow cell group (p=0.59). After 6 months, mean global LVEF had increased by 0.7 percentage points in ...Continue Reading

References

Dec 1, 1982·Circulation·E Braunwald, R A Kloner
Apr 5, 2001·Nature·D OrlicP Anversa
Jun 23, 2001·The New England Journal of Medicine·G MontalescotUNKNOWN ADMIRAL Investigators. Abciximab before Direct Angioplasty and Stenting in Myocardial Infarction Regarding Acute and Long-Te
Jul 6, 2001·Cell·H M BlauJ M Weimann
Mar 29, 2002·The New England Journal of Medicine·Gregg W StoneUNKNOWN Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Investigators
Sep 21, 2002·Lancet·Eriko Tateishi-YuyamaUNKNOWN Therapeutic Angiogenesis using Cell Transplantation (TACT) Study Investigators
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Arup ChakrabortyC Wayne Smith
Feb 26, 2003·Circulation·Emerson C PerinJames T Willerson
Aug 9, 2003·The New England Journal of Medicine·Martin Kørbling, Zeev Estrov
Dec 6, 2003·Circulation Research·Tibor ZiegelhoefferWolfgang Schaper

❮ Previous
Next ❯

Citations

Nov 16, 2011·JAMA : the Journal of the American Medical Association·Jay H TraverseUNKNOWN Cardiovascular Cell Therapy ResearchNetwork
Sep 6, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·G SteinhoffA D Ho
Apr 28, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·J AignerE Wintermantel
Oct 27, 2004·Der Internist·B Hertenstein, A Ganser
May 6, 2009·Pediatric Cardiology·Jason T LamKarl-Ludwig Laugwitz
Oct 6, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Frank M BengelStefanie Dimmeler
Jun 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·L BindslevJ Kastrup
Jan 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Giovanni Lucignani
Sep 9, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter J PsaltisMartin Rodriguez-Porcel
Oct 9, 2007·European Radiology·Yuxiang Ye, Jan Bogaert
Jul 8, 2011·European Radiology·Alessandro RuggieroMonique R Bernsen
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·V SchächingerA M Zeiher
Aug 7, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·F GrundmannJ Müller-Ehmsen
Dec 14, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·U LaufsM Böhm
May 30, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Michael BrehmBodo-Eckehard Strauer
Oct 19, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Johanna A MiettinenHeikki V Huikuri
Jun 3, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·David M LeistnerBirgit Assmus
Oct 12, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Paulino A AlvarezAlejandro Barbagelata
Oct 21, 2005·Basic Research in Cardiology·H C OttD A Taylor
Nov 1, 2005·Basic Research in Cardiology·Michael R Rosen
Oct 21, 2005·Basic Research in Cardiology·Buddhadeb Dawn, Roberto Bolli
Oct 21, 2005·Basic Research in Cardiology·Jeffrey M Zimmet, Joshua M Hare
Dec 31, 2005·Basic Research in Cardiology·Mihail Hristov, Christian Weber
Mar 8, 2008·Basic Research in Cardiology·Dara L Kraitchman, Jeff W M Bulte
Aug 8, 2012·Cell and Tissue Research·Miao TengYueSheng Huang
Nov 10, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Fangming Lin
Apr 10, 2007·Annals of Biomedical Engineering·Bryce H DavisDoris A Taylor
Nov 26, 2005·Angiogenesis·Daniela Tirziu, Michael Simons
Jul 19, 2012·Bulletin of Experimental Biology and Medicine·V I KonenkovA M Karaskov
Mar 2, 2011·The International Journal of Cardiovascular Imaging·Maythem SaeedMark Wilson
May 27, 2008·Cardiovascular Drugs and Therapy·Ferdinand H Bahlmann
Nov 30, 2006·Heart Failure Reviews·Frank M Bengel
Aug 29, 2006·Heart Failure Reviews·E LeontiadisD V Cokkinos
Aug 29, 2006·Heart Failure Reviews·Daniel J GoldsteinRobert E Michler
Aug 2, 2007·Heart Failure Reviews·Marton VertesaljaiPeter Andreka
Sep 30, 2006·Journal of Thrombosis and Thrombolysis·Patrick K Y Goon, Gregory Y H Lip

❮ Previous
Next ❯

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