Intracoronary autologous bone marrow-derived mononuclear cell transplantation improves coronary collateral vessel formation and recruitment capacity in patients with ischemic cardiomyopathy: a combined hemodynamic and scintigraphic approach

Angiology
Yelda TayyareciYilmaz Nisanci

Abstract

This study investigated the effects of intracoronary autologous bone marrow-derived mononuclear cell (BMC) transplantation on coronary microcirculation. Fifteen patients with ischemic cardiomyopathy were treated by intracoronary infusion of BMCs via the patent infarct-related artery. The thermodilution-derived coronary flow reserve, index of microvascular resistance, pressure-derived collateral flow index, and coronary wedge pressure were measured at baseline and at 6 months. Successive balloon inflations during BMC transplantation were performed to observe the recruitment in pressure-derived collateral flow index and coronary wedge pressure, and the percentage changes between baseline and 6 months were calculated. The mean (SD) coronary flow reserve increased from 1.3 (0.4) to 2.1 (0.5), and the mean (SD) index of microvascular resistance decreased from 44.9 (24.4) to 21.2 (14.1) (P = .001 for both). The mean (SD) improvement in pressure-derived collateral flow index (from 0.14 [0.05] to 0.22 [0.08]) was also statistically significant (P = .001). Similarly, the percentage improvements in pressure-derived collateral flow index and coronary wedge pressure were statistically significant (P = .01 for both). The percentage improvem...Continue Reading

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Citations

Sep 19, 2009·Regenerative Medicine·Thorsten Reffelmann, Robert A Kloner
Sep 28, 2010·Regenerative Medicine·Thorsten Reffelmann, Robert A Kloner
Feb 2, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Yun LuanYi-Biao Wang
Apr 18, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuhei Kobayashi, William F Fearon
Apr 2, 2009·Current Opinion in Organ Transplantation

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