PMID: 15238826Jul 9, 2004Paper

Intracoronary brachytherapy with beta-radiation for the treatment of long diffuse in-stent restenosis

Coronary Artery Disease
Christoph SchukroDietmar Glogar

Abstract

To assess the efficacy of intracoronary brachytherapy with beta-radiation (Sr/Y) for the treatment of long diffuse in-stent restenosis (ISR). As recurrent ISR depends on intimal injury after coronary angioplasty, long in-stent restenotic lesions were defined as lesions with a treatment length >26 mm (lesion length >20 mm plus a treatment margin of 3 mm at each end). Seventy-eight patients with long ISR were treated at our institution with beta-brachytherapy after coronary angioplasty. Patients were irradiated with either an approximate dose of 12 Gy at 1 mm vessel wall depth or with 18 Gy at 1 mm vessel wall depth. Clinical follow-up was available for 69 patients and angiographic follow-up for 65 patients. Late lumen loss (LLL), binary restenosis (stenosis >50%), target lesion revascularization (TLR) and major adverse cardiac events (MACE) were assessed for a follow-up time of 6.6+/-2.2 months. Mean interventional treatment length was 46+/-18 mm. TLR was performed in all 23 patients with binary restenosis (33%). Death of cardiac cause was reported for two patients, one of whom did not undergo TLR. Thus, overall MACE rate was 35%. Recurrent ISR was significantly more frequent in patients with geographic miss. Comparison of the d...Continue Reading

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Citations

Feb 13, 2007·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Karel K J KuiperJan Erik Nordrehaug
Sep 15, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Christoph SchukroDietmar Glogar

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