Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural-molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

European Heart Journal
Sunwon KimJin Won Kim

Abstract

Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural-molecular imaging with indocyanine green (ICG) can estimate inflammation in swine coronary artery. After administration of clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid coronary imaging (20 mm/s pullback speed) using a fully integrated OCT-NIRF catheter was safely performed in 12 atheromatous Yucatan minipigs and in 7 drug-eluting stent (DES)-implanted Yorkshire pigs. Stronger NIRF activity was identified in OCT-proven high-risk plaque compared to normal or saline-injected controls (P = 0.0016), which was validated on ex vivo fluorescence reflectance imaging. In vivo plaque target-to-background ratio (pTBR) was much higher in inflamed lipid-rich plaque compared to fibrous plaque (P < 0.0001). In vivo and ex vivo peak pTBRs correlated significantly (P < 0.0022). In vitro cellular ICG uptake and histological validations corroborated the OCT-NIRF findings in vivo. Indocyanine green colocalization with macrophages and lipids of human plaques was confirmed wit...Continue Reading

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Citations

Sep 30, 2016·Thrombosis and Haemostasis·Luca LiberaleFederico Carbone
Feb 13, 2018·Current Cardiology Reports·Csilla CelengRichard A P Takx
Jan 25, 2018·European Heart Journal·Thomas F Lüscher
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Dec 21, 2020·JACC. Cardiovascular Imaging·Sunwon KimJin Won Kim
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Haitham Khraishah, Farouc A Jaffer
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Jun 8, 2021·Frontiers in Cardiovascular Medicine·Zhaoyue LiYingfeng Tu
Jul 30, 2016·Current Opinion in Lipidology·Margreet R de Vries, Paul H A Quax

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