Intracoronary genistein acutely increases coronary blood flow in anesthetized pigs through beta-adrenergic mediated nitric oxide release and estrogenic receptors

Endocrinology
Elena GrossiniG Vacca

Abstract

Various studies have suggested that the phytoestrogen genistein has beneficial cardioprotective and vascular effects. However, there has been scarce information regarding the primary effect of genistein on coronary blood flow and its mechanisms including estrogen receptors, autonomic nervous system, and nitric oxide (NO). The present study was planned to determine the primary effect of genistein on coronary blood flow and the mechanisms involved. In anesthetized pigs, changes in left anterior descending coronary artery caused by intracoronary infusion of genistein at constant heart rate and arterial pressure were assessed using ultrasound flowmeters. In 25 pigs, genistein infused at 0.075 mg/min increased coronary blood flow by about 16.3%. This response was graded in a further five pigs by increasing the infused dose of the genistein between 0.007 and 0.147 mg/min. In the 25 pigs, blockade of cholinergic receptors (iv atropine; five pigs) and alpha-adrenergic receptors (iv phentolamine; five pigs) did not abolish the coronary response to genistein, whose effects were prevented by blockade of beta(2)-adrenergic receptors (iv butoxamine; five pigs), nitric oxide synthase (intracoronary N(omega)-nitro-L-arginine methyl ester; fiv...Continue Reading

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Citations

Jan 22, 2013·Clinical and Experimental Pharmacology & Physiology·Ganyapong ChaturapanichChumpol Pholpramool
Apr 10, 2009·PloS One·Naohito KitamuraMasahisa Yamada
Jul 12, 2011·European Journal of Pharmacology·Noboru Toda, Hiroshi Toda
Jun 15, 2013·British Journal of Pharmacology·Loubina FazalJane-Lise Samuel
Oct 16, 2012·Nitric Oxide : Biology and Chemistry·Shabnam M NaminNikolaos M Tsoukias
Nov 26, 2010·European Journal of Pharmacology·Biguang TuoHui Dong
Jun 8, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Yasina B SomaniDavid N Proctor
Jan 5, 2018·Journal of Vascular Research·Claudio MolinariFrancesca Uberti

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