Intracoronary Hypothermia Before Reperfusion to Reduce Reperfusion Injury in Acute Myocardial Infarction: A Novel Hypothesis and Technique

Therapeutic Hypothermia and Temperature Management
Luuk C OtterspoorNico H J Pijls

Abstract

Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients. Furthermore, systemic cooling can cause adverse effects such as severe shivering, volume overload, and an enhanced adrenergic state. In most randomized clinical trials, however, subgroups of patients with anterior myocardial infarction that reached the target temperature before reperfusion did show a reduction in infarct size. To transform therapeutic hypothermia into a clinically feasible treatment for AMI, its method must be modified. An ideal technique should be quick enough to achieve sufficient myocardial hypothermia before reperfusion, without significant delay a...Continue Reading

References

Jul 1, 1994·Cardiovascular Research·G L ChienD M van Winkle
Mar 10, 1999·Cardiovascular Research·S L Hale, R A Kloner
Sep 24, 2005·Basic Research in Cardiology·Michael MaengHenning R Andersen
Jan 4, 2007·JAMA : the Journal of the American Medical Association·UNKNOWN APEX AMI InvestigatorsFrans Van de Werf
Jan 16, 2007·Journal of the American College of Cardiology·Hiromasa OtakeMitsuhiro Yokoyama
Jul 31, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xue-Han NingMichael A Portman
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Jun 26, 2009·Critical Care Medicine·Kees H Polderman
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Zuo-Hui ShaoTerry L Vanden Hoek
Aug 31, 2010·European Heart Journal·Adriaan A VoorsUNKNOWN HEBE III Investigators
Dec 2, 2011·Cardiovascular Research·Renaud TissierAlain Berdeaux
Jan 6, 2012·The New England Journal of Medicine·Elizabeth G Nabel, Eugene Braunwald
Mar 5, 2013·American Heart Journal·Padma KaulFinlay A McAlister
Mar 26, 2013·Journal of the American Heart Association·Sharon L HaleRobert A Kloner
Mar 29, 2013·European Heart Journal·Georg M FröhlichDerek J Hausenloy
Dec 20, 2013·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Oct 2, 2014·Therapeutic Hypothermia and Temperature Management·Michael J HerringRobert A Kloner
Jul 8, 2015·Trends in Pharmacological Sciences·Christopher B FordyceChristopher B Granger
Aug 14, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Luuk C OtterspoorNico H J Pijls
Sep 1, 2015·The New England Journal of Medicine·Thien-Tri CungMichel Ovize
Sep 10, 2015·European Heart Journal·Navin K Kapur, Richard H Karas
Dec 31, 2015·European Heart Journal. Acute Cardiovascular Care·Luis O ChavezJoseph Varon
Apr 9, 2016·Journal of the American College of Cardiology·Gregg W StoneOri Ben-Yehuda

❮ Previous
Next ❯

Citations

Sep 4, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Thomas L MerrillMatthew J Gillespie
Apr 19, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Brunilda AlushiSalvatore Cassese
Apr 6, 2021·Therapeutic Hypothermia and Temperature Management·Benjamin S AbellaJack L Martin
Aug 19, 2020·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Yazan Bashtawi, Zakaria Almuwaqqat

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02753478

Software Mentioned

SINTAMI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.