Intracoronary verapamil rapidly terminates reperfusion tachyarrhythmias in acute myocardial infarction

Chest
Masaya KatoDaiji Hasegawa

Abstract

The restoration of coronary flow after transient ischemia immediately induces life-threatening ventricular tachyarrhythmias. Although most of these arrhythmias disappear spontaneously, some of them induce serious hemodynamic changes. This retrospective study investigates the efficacy of therapy with intracoronary verapamil to terminate reperfusion-induced ventricular tachyarrhythmias in patients with acute myocardial infarction (AMI). Between February 1992 and February 2003, 390 patients with a diagnosis of AMI were enrolled into the study. All patients received mechanical revascularization therapy within 6 h of onset of symptoms, and 109 patients experienced reperfusion-induced tachyarrhythmias. A subset of these patients was treated with intracoronary verapamil (0.25 to 1.0 mg) to terminate the reperfusion-induced tachyarrhythmia. They were evaluated for immediate termination of the tachyarrhythmias, hemodynamic changes, resumption rates, and major complications. Thirty-one patients (28%) were treated with intracoronary verapamil for the immediate termination of reperfusion-induced ventricular tachyarrhythmias. These tachyarrhythmias included 6 premature ventricular contractions, 19 accelerated idioventricular rhythms, 3 vent...Continue Reading

References

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Citations

Dec 15, 2010·Molecular Pharmacology·Pamela BergsonDorothy A Hanck
Mar 16, 2011·Anesthesiology Research and Practice·Hitoshi YuiKazu-Ichi Yoshida
Nov 26, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Svenna VerhielRene van der Hulst
Nov 29, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Long CunLrou Shuyi
May 16, 2006·Molecular Pharmacology·Benjamin S FreezeDorothy A Hanck
Jun 2, 2020·Frontiers in Pharmacology·Arpad Tosaki
Mar 25, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Moslem NajafiReza Badalzadeh

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