Intracorporeal glucose disposal during hemodialysis after a standardized glucose load

ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs
D SchneditzKarl Thomaseth

Abstract

The aim of this study was to quantify intracorporeal clearance and disposal of glucose after the administration of a standardized glucose load during regular hemodialysis done in stable and non-diabetic patients and to account for effects of extracorporeal clearance. A standardized load of glucose was administered approximately 30 min after starting hemodialysis with a constant dialysate glucose of 5.0 +/- 0.2 mmol/L. Glucose in the arterial line blood and in dialysate outflow was measured at baseline and in short intervals for a period of 1 h after the infusion. Tests were repeated within 1 week. Nine patients completed the study. Extracorporeal blood and dialysate flows were 304 +/- 34 and 500 mL/min, respectively. The intracorporeal clearance of glucose was 327 +/- 137 mL/min and 69.1 +/- 9.4% of total glucose clearance. Mass balance assessed from dialysate samples showed that 60.1 +/- 10.5% of glucose injected was disposed intracorporeally. The fraction of intracorporeal clearance and the fraction of intracorporeal glucose disposal were highly correlated (r = 0.94, p < 0.0001). The fraction of glucose disposed in hemodialysis patients can be determined from the amount of glucose injected and from the amount of glucose remov...Continue Reading

References

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Citations

Sep 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel SchneditzHerwig Holzer
Mar 29, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Rajendra Pratap SinghEdward A Ross
Mar 25, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzHildegard Hafner-Giessauf
Aug 27, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Roza Czabak-GarbaczBarbara Obermayer-Pietsch
Nov 1, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzJacek Waniewski
Dec 25, 2013·The International Journal of Artificial Organs·James M StevensonBruce A Mueller
Jan 13, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Daniel SchneditzMark Hoehlein
Feb 12, 2021·Diabetes Research and Clinical Practice·Longin NiemczykStanisław Niemczyk

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