Intracortical connectivity of layer VI pyramidal neurons in the somatosensory cortex of normal and barrelless mice

The European Journal of Neuroscience
Fabien PichonEgbert Welker

Abstract

In mice, barrels in layer IV of the somatosensory cortex correspond to the columnar representations of whisker follicles. In barrelless (BRL) mice, barrels are absent, but functionally, a columnar organization persists. Previously we characterized the aberrant geometry of thalamic projection of BRL mice using axonal reconstructions of individual neurons. Here we proceeded with the analysis of the intracortical projections from layer VI pyramidal neurons, to assess their contribution to the columnar organization. From series of tangential sections we reconstructed the axon collaterals of individual layer VI pyramidal neurons in the C2 barrel column that were labelled with biocytin [controls from normal (NOR) strain, 19 cells; BRL strain, nine cells]. Using six morphological parameters in a cluster analysis, we showed that layer VI neurons in NOR mice are distributed into four clusters distinguished by the radial and tangential extent of their intracortical projections. These clusters correlated with the cortical or subcortical projection of the main axon. In BRL mice, neurons were distributed within the same four clusters, but their projections to the granular and supragranular layers were significantly smaller and their tangent...Continue Reading

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Citations

Nov 21, 2014·Cerebral Cortex·Philipp SchnepelClemens Boucsein
Dec 1, 2012·Progress in Neurobiology·Dirk FeldmeyerCornelius Schwarz
Oct 11, 2013·Cerebral Cortex·Karlijn I van AerdeDirk Feldmeyer
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May 28, 2019·Frontiers in Neuroanatomy·Sheena Yin Xin TiongMakoto Sato
Aug 2, 2019·Nature Reviews. Neuroscience·Carl C H Petersen
May 17, 2018·Frontiers in Neuroanatomy·Takayuki YamashitaCarl C H Petersen
Aug 21, 2020·Physiological Reviews·Jochen F Staiger, Carl C H Petersen
Mar 6, 2021·PeerJ·Thomas F Burns, Ramesh Rajan

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Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.