Intracortical microstimulation of bilateral frontal eye field

Journal of Neurophysiology
N FujiiJ Tanji

Abstract

We trained two monkeys to perform a fixation task. Intracortical microstimulation (ICMS) was applied to the monkey frontal eye field (FEF) while monkeys were fixating on one of five fixation LEDs. The ICMS was applied in two different manners. Under the single stimulation condition, ICMS was delivered to either right or left FEF. Under the paired stimulation condition, bilateral FEF were successively stimulated with an interval of 30-250 ms. The single stimulation elicited contraversive saccades. As reported previously, these saccades were not much affected by initial eye positions, maintaining the same vector. In contrast, the paired stimulation elicited double-step saccades. The first of the paired stimulation elicited constant vector saccades, but the second of the paired stimulation evoked saccades whose vector varied greatly depending on the eye position at the start of individual saccades. The second saccades, starting from various initial positions, were directed to the endpoint of saccades that were elicited from the same FEF site under the single stimulation condition. Endpoints of second saccades varied little despite variations of intervals of the stimulation pairs, ranging from 60 to 150 ms. On the basis of these ob...Continue Reading

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Citations

Sep 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·N FujiiJ Tanji
Apr 20, 2006·PLoS Biology·Mark H Histed, Earl K Miller
Mar 11, 2000·Journal of Neurophysiology·N FujiiJ Tanji
May 19, 2007·The Journal of Physiology·Carlos R Cassanello, Vincent P Ferrera
Mar 31, 1999·Current Opinion in Neurology·B Gaymard, C Pierrot-Deseilligny
Dec 19, 2009·Journal of Neurophysiology·Adam N Phillips, Mark A Segraves
Nov 12, 2017·The Journal of Comparative Neurology·Iwona StepniewskaJon H Kaas
Aug 8, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Todd M Preuss, Steven P Wise

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