Intracortical modulation of somatosensory evoked fields during movement: evidence for selective suppression of postsynaptic inhibition

Brain Research
Juha Huttunen, Leena Lauronen

Abstract

As accurate finger movements depend on guidance by afferent sensory feedback information, it is of interest to examine how the cortical processing of afferent signals is altered during movement states compared with rest. In the present study we evaluated afferent input to the primary somatosensory cortex (SI) in human subjects performing a finger opposition task. We recorded somatosensory evoked magnetic fields (SEFs) in 6 healthy subjects to stimulation of left and right median nerves in a resting condition and during active right-sided finger movements. At the left SI, the SEFs to right (moving hand) median nerve stimulation showed a selective and robust reduction of the P35m deflection during movement compared with rest, while there were only minor non-significant changes in the other SEF deflections, including N20m, which represents the 1st excitatory cortical event after stimulation. In contrast, at the right SI the SEFs to left (non-moving hand) median nerve stimulation were modified in the opposite direction: the P35m deflection was slightly enhanced during right-sided movement, there being no significant changes in the other deflections. The results thus show that the P35m SEF deflection can be selectively reduced durin...Continue Reading

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